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Look Right for Signs of PAH Treatment Success

, 2025-04-21 11:48:00 To assess how a patient with pulmonary arterial hypertension (PAH) is faring on therapy, look at the right heart, said Anjali Vaidya, MD, in a presentation at the Annual Meeting of the American College of Cardiology. When it comes to right heart performance, “the echo doesn’t lie,” said Vaidya, a professor of…

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NIH’s Jay Bhattacharya says Trump DEI orders ‘misunderstood’

Jonathan Wosen , 2025-04-21 22:13:00 National Institutes of Health director Jay Bhattacharya on Monday asserted that the agency remains committed to research that advances the health of minorities — despite the Trump administration’s sharp focus on rolling back programs dealing with diversity, equity, and inclusion. Bhattacharya said that President Trump’s executive orders, which state that…

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Gut microbiome pattern predicts future heart attack risk in coronary heart disease patients

, 2025-04-21 23:48:00 Scientists have identified a gut microbiota profile that can help forecast future cardiovascular events in patients with heart disease, paving the way for more personalized treatment and early interventions. Study: A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study. Image Credit: Shutterstock AI Generator / Shutterstock.com A recent study…

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Immune Side Effects Tied to Better SCLC Survival

, 2025-04-21 12:00:00 TOPLINE: Immune-related adverse events (irAEs) were associated with significantly improved progression-free survival (PFS) and overall survival (OS) in patients with extensive-stage small cell lung cancer (SCLC) who received chemoimmunotherapy compared with that in those who did not experience such events. METHODOLOGY: Researchers conducted a retrospective analysis of 399 consecutive patients (median age,…

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Combining brain stimulation with speech therapy shows promise for restoring language in primary progressive aphasia

, 2025-04-21 21:13:00 Credit: Pixabay/CC0 Public Domain Primary progressive aphasia is a neurological condition that causes a gradual decline in language abilities. There is no cure or medication that can reverse or stop the progression of PPA. The standard practice in the clinical setting is speech-language therapy to help people with PPA maintain their ability…

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Obesity Is a Risk Factor for Remission Failure in Early RA

, 2025-04-21 12:00:00 TOPLINE:  Patients with obesity and early rheumatoid arthritis (RA) had an increased risk for remission failure after 6 months of starting methotrexate treatment, regardless of the presence of underlying comorbidities.  METHODOLOGY: Researchers analysed data from a population-based case-control study linked to the Swedish Rheumatology Quality Register to investigate the association of obesity…

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Aeroflow Health Unveils New Diabetes Management Program

Marissa Plescia , 2025-04-21 20:32:00 Aeroflow Health, a health tech company, last week announced a new diabetes management program, which aims to improve adherence, outcomes and care coordination for health plan members. Asheville, North Carolina-based Aeroflow Health was founded in 2001 and offers an array of medical devices covered by insurance. The company has four…

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White House new COVID-19 page promotes Wuhan lab leak theory

, 2025-04-21 18:34:00 The White House has replaced a federal website that provided information about COVID-19 with a web page titled “Lab Leak: The True Origins of COVID-19” that cites the controversial theory that the virus was leaked from a Wuhan lab in China. The previous websites, covidtests.gov and covid.gov, provided information on treatment options…

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Affordable Care Act worries mount, UnitedHealth stumbles

Bob Herman , 2025-04-21 14:57:00 Bob Herman covers health insurance, government programs, hospitals, physicians, and other providers — reporting on how money influences those businesses and shapes what we all pay for care. He is also the author of the Health Care Inc. newsletter. You can reach Bob on Signal at bobjherman.09. This is the…

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Using pilocarpine drops post goniotomy may reduce long-term glaucoma medication needs

, 2025-04-21 21:04:00 Credit: Unsplash/CC0 Public Domain Using pilocarpine eye drops following Kahook Dual Blade (KDB) goniotomy surgery may improve clinical outcomes for patients with glaucoma and reduce the need for future medications, according to new research published by faculty members and trainees in the Department of Ophthalmology at the University of Colorado School of…

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Ursolic acid modulates estrogen conversion to alleviate MASLD inflammation

, 2025-04-21 18:03:00 Background and aims The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) has been escalating annually, positioning it as the leading cause of chronic liver disease worldwide. Ursolic acid has demonstrated promising therapeutic efficacy in managing MASLD, thereby justifying the need for an in-depth exploration of its pharmacological mechanisms. This study aimed…

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Severe Herpes Zoster Raises Dementia Risk in Seniors

, 2025-04-21 12:00:00 TOPLINE: Older adults with severe herpes zoster were at a heightened risk of developing dementia, especially those aged 50-65 years, when compared with both matched control individuals from the general population and patients hospitalised for other infections. METHODOLOGY: Researchers conducted a cohort study from January 2001 to December 2023 in Italy to…

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Hippocratic AI partners with UAE services provider to expand into Middle East, North Africa

, 2025-04-21 18:58:00 United Arab Emirates-based Burjeel Holdings, a healthcare services provider, and Hippocratic AI, a generative AI company developing safety-focused large language models for healthcare, announced a strategic partnership to alter healthcare delivery.  Burjeel Holdings operates in parts of the Middle East and North Africa. Hippocratic AI and Burjeel announced the alliance during the…

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SCOTUS appears likely to uphold ACA preventive care mandate

Associated Press , 2025-04-21 19:13:00 WASHINGTON — The Supreme Court seemed likely to uphold a key preventive-care provision of the Affordable Care Act in a case heard Monday. Conservative justices Brett Kavanaugh and Amy Coney Barrett appeared skeptical of arguments that Obamacare’s process for deciding which services must be fully covered by private insurance is unconstitutional. The case…

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Cancer mortality continuing to decline, says report

, 2025-04-21 18:48:00 Overall cancer mortality rates declined from 2001 through 2022, while cancer incidence rates decreased from 2001 through 2013 and stabilized through 2021, according to the 2024 Annual Report to the Nation on the Status of Cancer published online April 21 in Cancer. Recinda L. Sherman M.P.H., Ph.D., from the North American Association…

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COVID-19 Linked to Kidney Risks in Children and Adolescents

, 2025-04-21 12:14:00 TOPLINE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was associated with increased risks for various adverse kidney outcomes, including new-onset chronic kidney disease (CKD) and worsening kidney function in patients younger than 21 years. Those with preexisting CKD or acute kidney injury (AKI) faced higher risks for severe adverse outcomes such…

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AstraZeneca & Daiichi Sankyo’s Enhertu Posts Positive Data as First-Line Breast Cancer Therapy

Frank Vinluan , 2025-04-21 17:36:00 A cancer drug from partners AstraZeneca and Daiichi Sankyo currently approved as a second-line or later treatment for metastatic breast cancer has interim clinical data showing it helped patients live longer without their disease worsening in the first-line setting, results that could support further expanding use of this targeted therapy….

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Tumor byproduct blocks immune cells from fighting cancer, offering new treatment target

, 2025-04-21 17:23:00 pEtn depletes DAG from CD8+ T cells and impairs their function. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025-01650-9 A team of researchers from the University of Chicago, in collaboration with researchers from the University of Pittsburgh, has identified a novel oncometabolite that accumulates in tumors and impairs immune cells’ ability to fight…

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New Acne-Specific Lasers Are Not Identical

, 2025-04-21 12:20:00 ORLANDO, Florida — Two lasers developed specifically to target the sebaceous gland were cleared by the US Food and Drug Administration (FDA) for the treatment of acne vulgaris in 2022, but it is unclear whether there are meaningful clinical differences between them. The good news has been the relatively high rates of…

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Medicare Advantage CEO: My baby is ugly…(video)

Arundhati Parmar , 2025-04-21 16:34:00 Straight talk is what everyone wants but rarely gets. At the Medicarians conference held earlier this month in Las Vegas, I had the opportunity to engage Sachin Jain, CEO of SCAN Health Plan, in a fireside health chat to talk about the current state of Medicare. While he extolled the…

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Researchers uncover genetic link between autism spectrum disorder and myotonic dystrophy type 1

, 2025-04-21 14:09:00 Scientists from The Hospital for Sick Children (SickKids) and University of Las Vegas Nevada (UNLV) have uncovered a genetic link between autism spectrum disorder (ASD) and a rare genetic condition called myotonic dystrophy type 1 (DM1). The study, published today in Nature Neuroscience, suggests that while ASD has previously been characterized by…

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Dramatic Uptake of Tirzepatide Seen for T2D and Weight Loss

, 2025-04-21 14:05:00 New data documented dramatic shifts in prescribing for both type 2 diabetes (T2D) and weight loss, particularly with the uptake of tirzepatide (Lilly) and declines in the use of older agents. Between 2021 and 2023, prescriptions of tirzepatide, semaglutide (Novo Nordisk), and sodium-glucose cotransporter 2 (SGLT2) inhibitors for people with T2D increased…

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Clinician Adoption: How HealthTech Can Overcome Key Barriers

Yegor Tsynkevich , 2025-04-21 14:50:00 Healthcare innovation is frequently accompanied with skepticism and resistance, even when it promises to improve patient outcomes and operational efficiency. Healthtech companies prioritize clinical validation, regulatory approvals, and performance metrics to ensure their technology meets industry standards. However, they often overlook one crucial factor: clinician adoption. Even the most promising…

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Readout Newsletter: Immunovant, Roivant, Sanofi, Regeneron

Meghana Keshavan , 2025-04-21 13:36:00 Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Morning. Today, we talk lots about tariffs — how they might impact drugmakers, patients, and even Ireland. Also, Novo Nordisk challenges Medicare over drug differentiation, and more.  Tariffs threaten…

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Saliva test plus AI could flag chemotherapy risk, early study results suggest

, 2025-04-21 13:46:00 Virginia Tech researchers John Janiga, Dzenis Mahmutovic (seated), Katherine Brown, and lead investigator Carla Finkielstein work together in the Molecular Diagnostics Laboratory at the Fralin Biomedical Research Institute at VTC to develop a test that could help doctors identify cancer patients at risk for severe chemotherapy side effects. Credit: Clayton Metz/Virginia Tech…

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White House Announces Drug Policy Priorities

, 2025-04-21 12:22:00 A recently released statement on Trump administration’s drug policy priorities called for a focus on stopping illicit drugs from coming into the United States, prosecuting those responsible for overdose deaths, expanded access to naloxone, and new campaigns “to inform the American people of the dangers of illicit drug use, the hope of…

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NIH grants, Covid guidance, pharma tariffs

Jason Mast , 2025-04-21 13:05:00 Get your daily dose of health and medicine every weekday with STAT’s free newsletter Morning Rounds. Sign up here. Good morning, Jason Mast here filling in for Theresa. The Morning Rounds editor has informed me that she has tired of all this debate over potato chips and the curious case of…

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Merging autonomy with manual control for wheelchair users

, 2025-04-21 12:38:00 The CoNav autonomous wheelchair developed by U-M engineers gives users the option of taking control. Credit: Vineet Kamat, Carol Menassa Autonomous technologies promise passengers travel without concern—the ability to get from Point A to Point B without needing to be engaged in the process. Yet passengers still don’t trust computers the way…

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In Heart Failure, Cellular Therapy Is Active

, 2025-04-21 12:29:00 CHICAGO — For patients with advanced heart failure, an injection of autologous mononuclear cells into damaged myocardia missed the primary endpoint in the sham-controlled, randomized, blinded CardiAMP-HF trial, but there was a strong signal of benefit, supporting further assessment. The study had a hierarchical win-ratio design, and the intervention met two of…

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What Are Health Systems’ Strategic Priorities in 2025?

Stephanie Baum , 2025-04-21 11:30:00 The healthcare investor conference MedCity INVEST, scheduled for May 20-21 at the Willis Tower in Chicago, will spotlight strategic priorities for health systems at a time when many face uncertainty amidst dramatic changes at HHS and with government funding at risk. A panel discussion on the strategic priorities of health…

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Why Cameras Are Popping Up in Eldercare Facilities

Paula Span , 2025-04-21 09:00:00 Paula Span The assisted living facility in Edina, Minnesota, where Jean Peters and her siblings moved their mother in 2011, looked lovely. “But then you start uncovering things,” Peters said. Her mother, Jackie Hourigan, widowed and developing memory problems at 82, too often was still in bed when her children…

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