Ed Silverman , 2025-04-22 13:22:00 Top of the morning to you, and a fine one it is. Clear blue skies and pleasant breezes are wafting across the Pharmalot campus, where the official mascots are foraging for their breakfast and rousing the neighbors. This means we are free to focus on the matters at hand —…
, 2025-04-22 14:11:00 Clearing senescent cells reduces orthopedic surgery-induced brain inflammation in aged mice. Credit: Madhurakkat Perikamana et al. A study in mice suggests that senescent cells are at least partially responsible for post-surgical delirium and similar conditions in elderly people—and identifies a combination of drugs that might be able to prevent the complication. Elderly…
, 2025-04-22 12:27:00 Chronic pain, a common and debilitating condition, often leads practitioners to prescribe opioids in escalating doses. The prescription of opioids has created a serious nationwide crisis that killed more than 107,000 Americans from December 2020 through December 2021, according to a report by the American Medical Association (“Nation’s opioid-related overdose and death…
, 2025-04-22 13:09:00 TOPLINE: Nearly 70% of children with low-risk peanut allergy tolerated a peanut oral food challenge, negating the need for allergy treatment, data from one center showed. METHODOLOGY: Researchers sought to determine how many children with a previously diagnosed low-risk peanut allergy could tolerate a full peanut oral food challenge during initial dose…
Kerry Love , 2025-04-22 13:15:00 In anticipation of the next major global pandemic, it is paramount that the global response to the Covid-19 pandemic is assessed. Especially now, as we see more diseases emerging in both unexpected areas and hosts in response to changing weather patterns and other major factors like globalization, we must be…
Michael Monostra , 2025-04-22 13:05:00 April 22, 2025 4 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Lizzy Lawrence and Brittany Trang , 2025-04-22 11:46:00 Brittany Trang, Ph.D., is a health tech reporter at STAT and writes the AI Prognosis newsletter. Follow her on Threads, Mastodon, and Bluesky. You can reach Brittany on Signal at btrang.01. WASHINGTON — The commissioner of the Food and Drug Administration welcomed three new leaders to the…
, 2025-04-22 12:00:00 The risk for cancer death is higher among children diagnosed in neighborhoods marked by persistent poverty, according to a study published online April 21 in Pediatrics. Emma Hymel, M.P.H., from the University of Nebraska Medical Center in Omaha, and colleagues used Surveillance, Epidemiology, and End Results-22 Registries Incidence Data with Census Tract…
, 2025-04-22 12:03:00 The highs and lows of blood glucose aren’t just an energy rollercoaster; they could be a key to detecting diabetes risk early and spare you a needle prick or two. Researchers at the University of Tokyo have identified a simple, noninvasive method for assessing blood glucose regulation – an essential factor in…
, 2025-04-22 12:00:00 TOPLINE: Moderately preterm birth independently predicted lower cognitive scores in late childhood. METHODOLOGY: This cross-sectional study analysed how gestational age affects cognition in children aged 9-10 years by using polygenic scores to separate biological from environmental influences. The study population included 5946 children (mean age, 9.9 years; 51.8% boys) who were stratified…
, 2025-04-22 10:22:00 A new study from South Korea has demonstrated the use of AI models to possibly diagnose and stratify attention deficit hyperactivity disorder by analysing eye images. FINDINGS Researchers from Yonsei University Health System have used four machine learning models and the AutoMorph deep learning pipeline to analyse approximately 1,108 retinal fundus photographs…
Ronnie Cohen , 2025-04-22 09:00:00 Eboni Tomasek expected to take home her newborn the day after he was born in a San Jose hospital. But, without explanation, hospital staff said they needed to stay a second night. Then a third. A nurse said her son had jaundice. Then said that he didn’t. She wondered if…
Rob Volansky , 2025-04-22 09:30:00 April 22, 2025 3 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later….
Jeff Levin-Scherz , 2025-04-22 08:30:00 On Tuesday, the Supreme Court heard oral arguments in Kennedy v. Braidwood Management, a case in which an employer is arguing that the formation of the U.S. Preventive Services Task Force (USPSTF) violates the Constitution’s appointments clause. The Affordable Care Act (ACA) regulations require that employer-sponsored health plans cover USPSTF-approved…
, 2025-04-22 10:35:00 Credit: MART PRODUCTION from Pexels English GPs in areas of socioeconomic deprivation endure increased job pressures related to managing complex patients, insufficient resources, and difficulty in finding locum cover, an analysis by University of Manchester researchers has shown. The researchers suggest that policymakers should increase funding so that deprivation is taken into…
, 2025-04-22 03:16:00 A Spanish food study reveals that even baby foods and meals in glass jars can contain concerning levels of plastic additives, with one chemical exceeding safety thresholds in infants under high-exposure scenarios. Study: Plastic additives in the diet: occurrence and dietary exposure in different population groups In a recent study published in the…
, 2025-04-22 09:56:00 The clinical training part of medical school means you finally get to put all the book learning, lectures, laboratories, and other preliminary lessons into practice. But it’s more than just the application of recently acquired knowledge. Rotations not only give you a chance to develop skills and care directly for patients but…
, 2025-04-22 08:30:00 Who is not there chasing the secret to a longer, healthier life? While miracle cures and anti-aging fads flood the market, a new study suggests that true secret to longevity may lie in something far simpler: avoiding certain risk factors by the age of 50. Everyday lifestyle choices can have a lasting…
Julie Appleby, KFF Health News , 2025-04-22 09:00:00 They’re the fixers, the ones who step in when Affordable Care Act enrollees have a problem with their coverage, like a newborn incorrectly left off a policy or discovering that a rogue broker had signed them up or switched their plan without consent. Specially trained caseworkers help…
Michael Monostra , 2025-04-21 13:37:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try again later….
David S. Ludwig and Mary E. Putt , 2025-04-22 09:00:00 Imagine a clinical trial with sedentary, overweight adults. One group is assigned to remain sedentary, the other to undergo intensive physical training with daily runs, calisthenics, and sports. After a week or two, the training group would probably feel sore and tired, and their endurance…
, 2025-04-22 06:54:00 Credit: Pixabay/CC0 Public Domain Long COVID can result in increased risk for a variety of serious health problems for young people, including those affecting the kidney, gut, and cardiovascular system, according to a group of new studies led by investigators at the Perelman School of Medicine at the University of Pennsylvania. “While…
, 2025-04-22 03:26:00 Primary progressive aphasia is a neurological condition that causes a gradual decline in language abilities. There is no cure or medication that can reverse or stop the progression of PPA. The standard practice in the clinical setting is speech-language therapy to help people with PPA maintain their ability to communicate. University of…
, 2025-04-22 07:39:00 Clinical ultrasound is invaluable for detecting atherosclerosis. However, methods to assess vascular areas with atheromatous plaques and their extent remain inconsistent and lack standardisation. To address this, the Spanish Society of Internal Medicine and the Spanish Society of Hypertension and Vascular Risk published two protocols for vascular risk assessment: VAScular UltraSound (VASUS)…
, 2025-04-22 07:42:00 As dementia cases surge globally, scientists are racing against time to uncover strategies that could slow or even prevent the devastating disorder marked by memory loss and cognitive decline. Now, new research points to a surprisingly familiar culprit and even a potential solution. A recent study revealed that managing high blood pressure,…
Leonard H. Calabrese, DO , 2025-04-21 13:41:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable…
John Wilkerson , 2025-04-21 08:30:00 When should six drugs count as one? That question is at the heart of an unusual challenge that the pharma company Novo Nordisk is pursuing against the federal government. And the answer could have major ramifications for the Medicare drug price negotiation program, a signature accomplishment of former President Biden…
, 2025-04-22 06:55:00 Basal cell carcinoma has low immunogenicity. Tumor cells express Foxc1 protein (red), which suppresses HLA class I (green) in the tumor cells. Credit: Shawn Demehri, Massachusetts General Hospital Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune-based therapies). Despite harboring the highest tumor mutational burden of…
, 2025-04-22 03:29:00 Use of psilocybin, the hallucinogenic chemical found in what is known as “magic mushrooms,” has increased significantly nationwide since 2019, according to a new study led by researchers at the University of Colorado Anschutz Medical Campus and Rocky Mountain Poison and Drug Safety. The study was published today in the Annals of…
, 2025-04-22 06:32:00 TOPLINE: Prophylaxis with efanesoctocog alfa, while reducing annualized bleeding rate by 77% compared with standard-care factor VIII in severe hemophilia A, is not cost-effective at current US pricing, requiring a > 47% price reduction to meet cost-effectiveness thresholds. METHODOLOGY: A Markov cohort model was constructed using data from the XTEND-1 study, which…
, 2025-04-22 05:38:00 Workouts are great, but what happens when your commitment to fitness pushes your body beyond its limit? It can even be deadly. For a 41-year-old fitness enthusiast from Scotland with an orange belt in karate, what began as an intense session soon spiraled into a medical emergency most gym-goers are unaware of….
Darrell E. White, MD , 2025-04-21 14:18:00 April 21, 2025 5 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . ” data-action=subscribe> Subscribe We were unable to process your request. Please try…
Paolo del Vecchio , 2025-04-21 08:30:00 At the age of 23, after years of mental health problems, addictions, and trauma, I found myself on a Philadelphia subway platform ready to end my life. Thankfully, I found help and got better. But due to the actions of the Trump administration, many others face a bleak future…
, 2025-04-22 05:00:00 Medication-induced disruption of sterol biosynthesis poses significant risks to brain development and function. Credit: Julio Licinio An editorial published in Brain Medicine raises the alarm about a previously overlooked threat to brain development and public health: the disruption of sterol biosynthesis by common prescription medications. The editorial, “Medication-induced sterol disruption: An overlooked…
, 2025-04-22 03:34:00 University of Oklahoma researchers recently launched the Children’s Environmental Health Center in the U.S. Southern Great Plains, a groundbreaking initiative dedicated to advancing research on children’s health and environmental exposures, following a year of preparation. Funded by a $1.8 million grant from the U.S. Environmental Protection Agency, this new center aims to…
, 2025-04-21 11:37:00 Migraine with aura is the most prominent individual risk factor for unexplained stroke in adults younger than 50 years, particularly in women and in those with patent foramen ovale (PFO), a new study showed. While investigators found that both traditional and nontraditional risk factors contributed significantly to cryptogenic ischemic stroke (CIS) risk…
Richard L. Lindstrom, MD , 2025-04-21 14:18:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable…
Adam Feuerstein , 2025-04-21 12:30:00 Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast The Readout Loud and author of the newsletter Adam’s Biotech Scorecard. You can reach Adam on Signal at stataf.54….
, 2025-04-22 04:10:00 Credit: Unsplash/CC0 Public Domain Middle-aged Americans have demonstrated some of the highest levels of loneliness in a new study assessing tens of thousands of 50-to-90-year-olds across 29 countries. The research, published in Aging & Mental Health, shows that loneliness generally increases with age—with only the United States and the Netherlands representing places…
, 2025-04-22 03:40:00 A new study offers insight into what is happening in our brains when our working memory must use its limited resources to remember multiple things. Researchers found that two parts of the brain work together to ensure that more brain resources are given to remember a priority item when a person is…
, 2025-04-22 02:38:00 TOPLINE: Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected monocytes, fibrocytes, and lymphocytes, leading to changes in gene expression and protein levels that may contribute to disease progression. METHODOLOGY: Researchers examined CLL cell–derived exosomes and their…
Barbara C. Erny, MD; Alex Young , 2025-04-21 14:18:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We…
Ed Silverman , 2025-04-21 13:18:00 Good morning, everyone, and welcome to another working week. We hope the weekend respite was relaxing and invigorating, because that oh-so familiar routine of deadlines, online meetings, and phone calls has predictably returned. But what can you do? The world, such as it is, continues to spin. So time to…
, 2025-04-21 18:40:00 Adverse pregnancy outcomes (APOs) mediate a small proportion of the association between prepregnancy obesity and cardiovascular disease (CVD) risk in midlife, according to a study published in the April 22 issue of the Journal of the American College of Cardiology. Jaclyn D. Borrowman, Ph.D., from Northwestern University in Chicago, and colleagues examined…
, 2025-04-22 02:42:00 Using pilocarpine eye drops following Kahook Dual Blade (KDB) goniotomy surgery may improve clinical outcomes for patients with glaucoma and reduce the need for future medications, according to new research published by faculty members and trainees in the Department of Ophthalmology at the University of Colorado School of Medicine. “The KDB goniotomy is a minimally invasive glaucoma…
, 2025-04-21 11:39:00 Emerging evidence suggests that how you eat, as well as what you eat, can have an impact on obesity. Recent research showed that the number of chews and bites and meal duration can affect feelings of hunger and satiety and, by extension, how much food is consumed. In a recent small study…
Caitlyn Stulpin , 2025-04-21 18:26:00 April 21, 2025 2 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
Mike Damiano — Boston Globe and Hilary Burns — Boston Globe , 2025-04-21 22:00:00 Harvard University sued the Trump administration on Monday, alleging that the government’s campaign to alter the school’s policies while cutting off research funding is unconstitutional. In a lawsuit filed in federal court in Boston, the university’s lawyers argued that the government’s “attempt…
, 2025-04-21 19:22:00 Credit: RDNE Stock project from Pexels Deciding whether to start hormone therapy during the menopause transition, the life phase that’s the bookend to puberty and when a woman’s menstrual cycle stops, is a hotly debated topic. While hormone therapy—replacing the hormones that were previously produced by the body with synthetic medication—is recommended…
, 2025-04-22 01:23:00 Women who experience urinary incontinence after giving birth may get just as much relief from telehealth as they do from physical therapy, a new UC San Francisco study has found. It is the first comparison of telehealth to in-person pelvic physical therapy, and the results open the door to new ways of…