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Interferon regulatory factor 8 identified as key driver of liver fat buildup in NAFLD

, 2025-04-23 03:04:00 Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance. Interferon regulatory factor 8 (IRF8) is well known for its roles in immune cell differentiation and tumor pathogenesis; however, its role in regulating glucose homeostasis and lipid metabolism remains unclear. This research, published in the Genes &…

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Underfunding Halts Malnutrition Treatments in Ethiopia

, 2025-04-22 11:52:00 GENEVA (Reuters) -The World Food Programme suspended malnutrition treatment for 650,000 malnourished women and children in Ethiopia this week due to severe funding shortages, the U.N. agency said, with millions more at risk of losing access to aid. WFP gets financing from 15-20 donors including the United States but many of them…

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Post-Pandemic Surge of Group A Strep Infections in Children

, 2025-04-22 11:54:00 TOPLINE: Data over a 32-year period showed that the incidence of invasive group A streptococcal (iGAS) infections in children remained stable before 2011, increased until 2020, declined during the pandemic, and subsequently sharply rose in 2023, with a notable surge contributed by respiratory tract infections. METHODOLOGY:  Researchers evaluated the incidence and clinical…

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Women’s Health Initiative, known for hormone trials, to lose U.S. funds

Elizabeth Cooney , 2025-04-22 21:24:00 Elizabeth Cooney is a cardiovascular disease reporter at STAT, covering heart, stroke, and metabolic conditions. Federal funding for the Women’s Health Initiative, which as one of the largest research projects in women’s health has shaped treatment of menopause, osteoporosis, and nutrition, will stop in September, the program said Tuesday in…

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Federal COVID websites now promote lab leak theory

, 2025-04-22 23:50:00 by I. Edwards The Trump administration has replaced two major federal websites for COVID information with a new page that promotes the theory that the virus came from a lab in China. COVID.gov and COVIDtests.gov, which once helped people order COVID tests and find public health information, now redirect to a new…

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Both Lifestyle and Mortality Poor in ADHD Patients Post MI

, 2025-04-22 12:00:00 TOPLINE: Adults with myocardial infarction (MI) and attention-deficit/hyperactivity disorder (ADHD) were more likely to smoke, use snus, and have histories of bleeding and chronic obstructive pulmonary disorder (COPD) than those without ADHD. Although ADHD was associated with a higher rate of all-cause mortality, these patients were less likely to participate in follow-up…

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Safer opioid supply improves health outcomes among people at high risk of overdose

, 2025-04-22 22:30:00 Credit: Etatics Inc. from Pexels Research from ICES and Unity Health Toronto shows that safer opioid supply programs and methadone both reduce opioid overdoses, health care utilization, and costs. The work appears in The Lancet Public Health. Safer opioid supply (SOS) programs provide pharmaceutical-grade opioids such as hydromorphone to people struggling with…

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AGA announces $2.4 million in research funding for 74 recipients

, 2025-04-22 19:02:00 The American Gastroenterological Association (AGA) is proud to announce the selection of 74 recipients to receive $2.4 million in research funding through the annual AGA Research Foundation Awards Program. AGA also announces today the addition of 10 pilot grants, totaling $400,000 in funding, to the 2026 awards portfolio to ensure that scientific discovery…

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Severity Increases Hospital Mortality in Hyponatraemia

, 2025-04-22 12:00:00 TOPLINE: Patients with hyponatraemia exhibited higher 30-day mortality rates than those with normal sodium concentrations, and over time, the risk for mortality declined among patients with mild hyponatraemia; however, this trend was less pronounced in those with moderate hyponatraemia and absent in those with severe hyponatraemia. METHODOLOGY: Researchersanalysed the risk for mortality…

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Bristol’s Cobenfy disappoints as supplemental antipsychotic drug

Jason Mast , 2025-04-22 21:36:00 A landmark new treatment for schizophrenia didn’t provide additional benefits to patients when given on top of standard-of-care therapy, Bristol Myers Squibb announced Tuesday. The drug, Cobenfy, was approved last year based on data from three randomized studies comparing the drug to placebo. It was the first new mechanism-of-action approved…

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FDA approved anti-inflammatory drug shows promise for treating alcohol use disorder and pain

, 2025-04-22 19:20:00 A preclinical study from scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity-two issues that commonly co-occur with alcohol use disorder (AUD). The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast-a phosphodiesterase-4…

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Will These New Drugs Change Your Practice?

, 2025-04-22 12:09:00 A quartet of new medications may improve care of patients with hypertension, urinary tract infections (UTIs), hot flashes, and liver disease, said Gerald W. Smetana, MD, professor of medicine at Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, in a presentation at the American College of Physicians (ACP-IM) Internal Medicine…

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‘I Shudder to Think What Could Have Happened to Me’

, 2025-04-22 20:13:00 Beyoncé‘s mom, Tina Knowles, has opened up about her private battle with breast cancer and shared and urgent message for other women. The author, who recently published her book “Matriarch,” spoke with People about the harrowing time in her life. In the interview, she reveals that she was diagnosed with stage 1…

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Reveleer acquires Novillus to enhance health plan-provider collaboration

, 2025-04-22 17:11:00 California-based healthcare data and analytics company Reveleer has acquired Novillus, which offers a workflow platform for health plans.  Reveleer, formerly Health Data Vision, provides an AI-enabled platform for payers aimed at advancing value-based care. The company offers workflow, data and analytics tools for risk adjustment, quality improvement and member management. It also…

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NIH research grant restrictions, a ban on more food dyes

John Wilkerson , 2025-04-22 19:47:00 You’re reading the web edition of D.C. Diagnosis, STAT’s twice-weekly newsletter about the politics and policy of health and medicine. Sign up here to receive it in your inbox on Tuesdays and Thursdays. STAT won its first National Magazine Award for General Excellence. Not bad, huh? Help us keep up the good…

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Wording matters in parental support for adolescent medical services, study finds

, 2025-04-22 19:32:00 Credit: Unsplash/CC0 Public Domain A study by researchers from Emory University’s Rollins School of Public Health and Vanderbilt University Medical Center has found that parental support for adolescent medical consent varied significantly depending on how the question was framed. Tennessee’s Mature Minor Doctrine, which allowed for adolescent medical consent in some instances,…

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Obesity alters the rhythm of liver’s starvation response

, 2025-04-22 19:09:00 Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been…

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Stop Smoking Now to Protect Your Vision, Experts Warn

, 2025-04-22 12:31:00 TOPLINE: Current smokers faced up to 12-fold higher risk for age-related macular degeneration, a threefold higher risk for primary open-angle glaucoma, and a fourfold higher risk for cataracts. The risk for certain ocular disorders persisted among individuals with a previous history of smoking. METHODOLOGY: Researchers searched PubMed, Scopus, and Web of Science…

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STAT Breakthrough West 2025: A behind-the-scenes look

Matthew Herper , 2025-04-22 18:12:00 A behind-the-scenes look at this year’s agenda Dear readers: You come to STAT for tough, smart journalism that helps you think about big topics like how AI will change medicine and the upheaval enveloping U.S. science. So join us in San Francisco on May 14, when we’ll do it live.  Those…

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Heavy Drinking Tied to Risk for Brain Lesions

, 2025-04-22 12:37:00 TOPLINE: Consuming at least eight alcoholic drinks per week was associated with a 133% higher risk for hyaline arteriosclerosis, a brain lesion associated with memory and thinking problems, than not drinking, new research showed. A history of heavy drinking was linked to an 89% higher risk for these lesions, as well as…

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Biolinq raises $100M for intradermal glucose sensor for type 2 diabetes

, 2025-04-22 15:26:00 Biolinq, a health technology company developing precision multi-analyte wearable biosensors for metabolic health, announced it secured $100 million in Series C funding.  Alpha Wave Ventures led the round with participation from existing investors AXA IM Alts, M Ventures, LifeSci Venture Partners, RiverVest Venture Partners, Hikma Ventures, Taisho Pharmaceutical, Features Capital and Aphelion…

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Predicting how an autistic child will develop cognitively

, 2025-04-22 15:42:00 Combining genetic variants and developmental milestones to predict intellectual disability (ID) in autistic individuals. Credit: JAMA Pediatrics (2025). DOI: 10.1001/jamapediatrics.2025.0205 Will a child who’s evaluated for autism later develop an intellectual disability? Can this be accurately predicted? Early-childhood experts in Quebec say they’ve have come up with a better way to find…

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Sex differences in substance use patterns among individuals with panic disorder

, 2025-04-22 11:57:00 In a comprehensive Genomic Press peer-reviewed research article, researchers have revealed compelling evidence that biological sex significantly influences substance use patterns among individuals with panic disorder, with implications for both clinical assessment and treatment strategies. The noteworthy study, published today in the journal Genomic Psychiatry, examined associations between panic disorder and both…

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TILs Plus Pembro Show Efficacy in GI Cancers

, 2025-04-22 12:44:00 Neoantigen-specific tumor-infiltrating lymphocytes (TILs) plus pembrolizumab demonstrate efficacy against treatment-refractory gastrointestinal (GI) cancers in early results from a phase 2 trial. This is the first clinical trial to show that TILs can deliver responses in patients with metastatic GI cancers, making it a notable advance in the efforts to adapt cellular immunotherapy…

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