Etavopivat, an oral activator of red blood cell pyruvate kinase, showed promise in reducing vaso-occlusive crises and improving hemoglobin levels in patients with sickle cell disease. Results from the HIBISCUS trial revealed a decrease in annualized vaso-occlusive crisis rates, an increase in hemoglobin levels, reduced fatigue, and improved hemolysis markers with etavopivat compared to placebo….
An outbreak of illness in a remote part of the Democratic Republic of the Congo with unknown cause has led to speculation that known diseases like malaria, pneumonia, influenza, Covid-19, or measles may be exacerbated by severe malnutrition. The area’s food insecurity, low vaccination coverage, and limited healthcare resources have contributed to the high number…
New guidelines for the diagnosis and management of premature ovarian insufficiency (POI) have been published, developed by an international team including women with lived experience. POI, defined as ovarian function loss before age 40, affects 4% of women globally and is linked to infertility, psychological distress, and health risks. The updated 2024 guidelines cover symptoms,…
A recent study published in Hearing Research explores the relationship between naps and tinnitus, revealing that somatosensory modulations may lead to increased tinnitus loudness after naps. Factors such as snoring, sleep apnea, and muscle tonus can contribute to this phenomenon. The study involved 37 tinnitus patients and found that tinnitus loudness increased following naps. Snoring…
The addition of blinatumomab to chemotherapy significantly improved 3-year disease-free survival in pediatric patients with newly diagnosed, standard-risk B-cell acute lymphoblastic leukemia (B-ALL). A phase 3 trial showed a 61% improvement in disease-free survival when blinatumomab was added to standard treatments. The study included patients aged 1 to 10 years and with a specific white…
Dental anxiety and mistrust are common reasons why people avoid dental treatment. This leads to missed appointments, neglected tooth pain, and poor oral health. Emerging dental technologies are improving patient care and outcomes, reducing anxiety associated with treatments. Approximately 40 million Americans skip the dentist due to anxiety, impacting their oral health. Establishing trust and…
The Irish Pakistani Professionals Association (IPPA) organized its 3rd CME and 4th Annual Event with prominent guests including government ministers and the Pakistani Ambassador. The event focused on humanitarian medicine, medical research, and career progression for international medical graduates in Ireland. Presentations were given by experts in the field, and a poster presentation competition was…
Daratumumab monotherapy has shown to significantly delay progression of high-risk smoldering multiple myeloma to active multiple myeloma compared with active monitoring. The results of the AQUILA study revealed that daratumumab reduced the risk for progression or death by 51% and had a low rate of treatment discontinuation due to toxicities. The study included 390 adults…
The ASH 2024 conference featured industry leaders discussing the future of blood cancer treatment, emphasizing the potential for cures using innovative therapies. Data presented highlighted the disparities in access to bone marrow transplants for AML patients from disadvantaged backgrounds. Research on 9/11 first responders revealed a higher risk of blood cancers due to toxic exposure,…
Research shows that humans, monkeys, and apes have social knowledge to track social dynamics. Humans communicate events by emphasizing agents, actions, and patients in a sentence structure. Cross-linguistic studies reveal a universal bias for agents. An eye-tracking study with humans and apes showed quick identification of agents and patients in social scenes, particularly with food….
Researchers at Kyushu University discovered the connection between spatial distance in DNA and gene activity bursts. The folding and movement of DNA, as well as protein accumulation, change based on gene activity levels. This study, published in Science Advances, provides insight into gene expression complexities and potential therapeutic applications for gene expression-related diseases. Gene transcription…
Patients with multiple myeloma who receive IVIG prophylaxis during treatment with teclistamab have fewer infections and better overall survival compared to those who do not receive IVIG. The study included 225 patients with relapsed and/or refractory multiple myeloma, showing that IVIG prophylaxis led to a longer duration of infection-free survival and almost threefold longer median…
The three major pharmacy benefit managers, CVS Caremark, Express Scripts, and Optum Rx, have countersued the FTC after being accused of engaging in anticompetitive practices tied to insulin rebates. The PBMs claim the lawsuit is unconstitutional and are trying to defend themselves against the allegations. The FTC argues that the PBMs control a large portion…
The Blackrock Health Summit, themed “Better Together – Healthcare Horizons,” gathered thought leaders to discuss healthcare challenges, solutions, and opportunities. Speakers highlighted the impact of climate change on healthcare, the need for strong antimicrobial stewardship, and the importance of collaboration in addressing healthcare issues. Discussions centered around the future of healthcare, including access to new…
Financial toxicity is a significant issue for individuals with blood cancer, encompassing factors beyond just drug costs, such as childcare, transportation, and lost income. Addressing this issue requires efforts at the clinic, system, and policy levels. Proactively screening for financial toxicity and implementing financial navigation are key actions clinicians can take at the individual level….
Socioeconomic factors create barriers to bone marrow transplants for acute myeloid leukemia patients, leading to higher death rates in disadvantaged communities. Research at Fred Hutchinson Cancer Center found patients from these areas were less likely to receive transplants and more likely to die without one. Factors like education levels influenced access to treatment, with those…
A recent study explored the impact of sensory stimulation on increasing human visual working memory capacity. The study aimed to determine if manipulating brain oscillations through sensory entrainment could enhance working memory. Contrary to expectations, both faster and slower theta frequencies of stimulation significantly improved working memory capacity in participants. This finding suggests that sensory…
Researchers have developed a way to program immune cells to target glioblastoma and treat multiple sclerosis inflammation in mice. This technology will soon be tested in clinical trials for people with glioblastoma. Using a “molecular GPS” system, immune cells were guided into the brain to kill tumors without harming healthy tissue. The method was successful…
Phase 3 data from the LUNA 3 trial supports rilzabrutinib as a first-in-class oral Bruton tyrosine kinase (BTK) inhibitor for patients with previously treated immune thrombocytopenia (ITP). The study showed that rilzabrutinib led to rapid and durable platelet responses, reduced bleeding, improved quality of life, and decreased need for rescue therapy in patients with persistent…
The author shares their journey of being diagnosed with endometriosis after years of suffering from various medical issues. They highlight the complexity of the disease and the need for increased awareness, better training for healthcare professionals, and more funding for research. The author emphasizes the importance of listening to women’s health issues and advocating for…
Researchers from University of Galway and Arizona State University have made a significant breakthrough in understanding muscle atrophy, a major health concern for astronauts during space travel. By analyzing data from NASA’s GeneLab, the team identified key molecular pathways linked to muscle deterioration in microgravity. Their findings shed light on the role of glycosylation in…
An AI model accurately detected epileptic spasms in infants through smartphone videos, with an 83% correct identification rate. The researchers developed a digital tool for parents to upload videos of their infants’ movements to a secure platform for AI analysis, aiming to accelerate the diagnosis process. Early identification of infantile spasms is crucial for timely…
By 2030, radiologists predict that generative AI will be widely used in their written work. Medical imaging is already incorporating AI, with algorithms analyzing CT scans, MRIs, and X-rays, making up a majority of AI-based devices approved by the FDA. At the Radiological Society of North America meeting, large language models (LLMs) were highlighted as…
Katie Gaddini discusses the priorities of movements seeking to limit reproductive rights, particularly anti-abortion efforts. Following Trump’s presidency, there is uncertainty about how he will handle reproductive health in his second term. The pro-life movement may seek to legally redefine personhood to include embryos, impacting IVF treatments. Additionally, regulations on mifepristone, the “abortion pill,” are…
Branden Baptiste, diagnosed with sickle cell disease at a young age, struggled with chronic complications affecting his kidneys, lungs, joints, and eyes. Seeking a cure, he participated in a groundbreaking gene therapy trial called BEACON at Boston Children’s Hospital. Through base editing, the most precise form of gene therapy, Branden’s red blood cells were edited…
Researchers at the University of California San Diego School of Medicine have created a comprehensive map of changes in the blood system throughout a human’s lifetime. They analyzed gene expression in over 58,000 individual blood stem cells at different stages, from fetal development to old age. The study revealed shifts in blood cell production according…
A new analysis presented at the American Society of Hematology Annual Meeting suggests that omitting 24-hour urine testing from multiple myeloma response assessments does not compromise accurate tracking of patients’ responses to treatment. Evaluating patients’ responses using urine-free and traditional criteria led to nearly identical assessments in the study of 645 patients. The findings support…
Anthem Blue Cross Blue Shield’s decision to cap anesthesia coverage based on arbitrary time limits has drawn criticism from medical professionals for prioritizing profits over patient safety. The American Society of Anesthesiologists (ASA) raised concerns about this policy, which does not consider the complexity or duration of surgeries. Anthem claims the move aligns with federal…
Dr. Mario Pulido, Chief Medical Officer at Ascension St. Vincent’s in Florida, found that EMR companies could not provide a way to add an anticipated date of discharge feature to improve patient care. He discovered Wellsheet, an AI-powered solution that enhances EMR productivity and reduces burnout for clinicians. The technology also reduces the number of…
The annual Haematology Summit took place in Dublin on September 6, 2024, attracting healthcare professionals involved in the care of patients with haematological malignancies. Discussions focused on the latest insights into the diagnosis and treatment of diseases such as multiple myeloma, chronic lymphocytic leukaemia (CLL), and acute myeloid leukaemia (AML). Key speakers emphasized the importance…
A high-fiber plant-based diet was found to delay progression of precursor conditions to multiple myeloma in a study presented at the ASH Annual Meeting and Exposition. The NUTRIVENTION trial showed that this diet intervention improved quality of life, biomarkers of the disease, and modifiable risk factors. The study included 20 participants with MGUS or smoldering…
The ASH 2024 conference in San Diego featured updates on new treatments for rare diseases such as immune thrombocytopenia and sickle cell disease. Sanofi’s rilzabrutinib showed promising results in increasing platelet counts and reducing bleeding episodes in ITP patients. Novo Nordisk’s etavopivat pill reduced severe pain crises in sickle cell disease patients. Beam Therapeutics’ CRISPR-based…
The UK government has resurrected legislation to combat youth vaping and create a smoke-free generation by banning tobacco sales to those born after January 1, 2009. While this is a positive step, improving the country’s health record requires action on other leading causes of premature death and disability. Alcohol, as a type 1 carcinogen, leads…
Physical activity, such as daily walking, can offer various health benefits, including reducing the risk of diseases like heart disease and cancer. To maximize the benefits of walking, consider varying your speed, walking faster, adding weight with a weighted vest or backpack, incorporating hills or stairs, and practicing mindful walking. These strategies can enhance cardiovascular…
A study conducted by a research team at the University of Konstanz, led by toxicologist Ivano Amelio, has shown that different mutations of the tumor suppressor p53 have varying effects on pancreatic carcinomas. The p53 protein plays a crucial role in inhibiting cell proliferation and promoting cell death in case of DNA damage, but mutations…
A real-world retrospective analysis linked the bispecific antibodies epcoritamab and glofitamab to somewhat poorer outcomes in relapsed or refractory large B-cell lymphoma compared to clinical trials. The study tracked 172 patients with a median follow-up of 5 months, finding median progression-free survival of 2.7 months and median overall survival of 7.2 months. Despite some patients…
In Africa, a mysterious illness with flu-like symptoms has claimed nearly 150 lives in southwest Congo. Health officials, including the WHO, are investigating the unidentified illness, which presents with symptoms such as fever, headache, cough, and anemia. The WHO has dispatched a team to collect samples for lab investigation and the CDC is offering technical…
Consumers are increasingly focusing on holistic wellness services, leading to a rise in demand for shoppable health and wellness care. These services allow consumers to compare prices and schedule non-urgent healthcare resources ahead of time. With rising healthcare costs, many consumers are opting for financing plans to pay for wellness services. Providers are facing increased…
The HSE West and Northwest Cancer Network has been accredited by the Organisation of European Cancer Institutes (OECI), making it one of only 20 such groups in Europe. The accreditation process involved a peer review visit by a panel of European experts, evaluating 345 standards across the region’s cancer programme. This accreditation is considered the…
Deegant Adhvaryu helped his parents apply for Medicaid and food benefits in June. Due to delays and incomplete applications, his parents, ages 71 and 76, were left without coverage in Georgia, even though they had it in Virginia. This was due in part to the implementation of the Georgia Pathways to Coverage program, which added…
Results of the randomized phase 3 LUNA 3 study showed that rilzabrutinib induced rapid and lasting platelet count expansion for patients with immune thrombocytopenia. The drug also improved overall response rate and quality of life compared to placebo. This BTK inhibitor had a low adverse event rate and demonstrated significant efficacy in a refractory patient…
The European Commission approved Novo Holdings’ $16.5 billion acquisition of Catalent, a contract drug manufacturer, removing obstacles to the deal. The acquisition, which has sparked debate over competition in the pharmaceutical industry, is still pending approval from the U.S. Federal Trade Commission. Novo Holdings, the parent company of Novo Nordisk, aims to buy Catalent due…
Global drug policies should shift from punishing drug users to a public health approach focused on reducing harm caused by drugs, according to the Global Commission on Drug Policy. The Commission advocates for the decriminalization of drug use and expanding harm reduction strategies to address rising overdose deaths, violence, and the strain on criminal justice…
A study led by Brigham and Women’s Hospital suggests that spending more time in bright light may improve mood by promoting better sleep. The study included over 6,600 participants and found that regular sleep was associated with lower depression symptoms. Participants who spent more time in bright light had more regular sleep, leading to lower…
The Horner–Wadsworth–Emmons (HWE) reaction is crucial in organic chemistry for creating conjugated carbonyl compounds used in various industries. Improving HWE reactions is a focus of research, with potential applications in developing anti-cancer compounds. Tokyo University of Science researchers have developed a highly selective HWE reaction method using a magnesium phosphonoenolate intermediate, allowing for isolated active…
Physicians reacted harshly to the fatal shooting of UnitedHealthcare CEO Brian Thompson due to frustrations and anger over the insurer’s routine denials of care. The incident sparked criticism towards the company’s practices, with some physicians sharing their negative experiences with prior authorizations and denials. While some expressed sympathy for Thompson’s death, others felt he reaped…
Anthem Blue Cross Blue Shield in Connecticut has decided to cancel its plan to limit anesthesia coverage for surgeries after facing backlash. The policy, which was supposed to start in February 2025, would have restricted coverage based on time limits, potentially leaving patients with out-of-pocket expenses. State Comptroller Sean Scanlon announced the reversal, stating that…
Artificial intelligence (AI) is transforming patient care by improving engagement, treatment outcomes, and reducing readmission rates in healthcare. AI-powered assistants guide patients through testing procedures, treatment plans, and insurance claims, enhancing patient understanding and adherence. Virtual health assistants offer personalized, data-driven support by analyzing health data and providing real-time guidance. These AI tools also address…
The introduction of a new vaccine for Respiratory Syncytial Virus (RSV) has led to a significant decrease in cases, hospitalizations, and ICU admissions in newborn infants this winter compared to the previous year. Over 9,300 babies have received the vaccine since September 1, resulting in only ten notified RSV cases, seven hospitalizations, and less than…
KFF Health News senior correspondent Arthur Allen discussed vaccine infrastructure fragility on The Atlantic’s “Radio Atlantic,” highlighting concerns about public health. Andy Miller discussed U.S. obesity rates on WUGA’s “The Georgia Health Report,” while Julie Appleby talked about health insurance options in Wisconsin on Wisconsin Public Radio’s “Wisconsin Today.” KFF Health News is a national…