Article

Age- and sex-stratified normal values for circulatory and ventilatory power during ramp exercise derived from a healthy Japanese population




doi: 10.1007/s00380-023-02258-5.


Online ahead of print.

Kohei Ashikaga 
1
, Haruki Itoh 
2
 
3
, Tomoko Maeda 
2
 
3
, Yuri Ichikawa 
4
, Shiori Tanaka 
2
, Akira Koike 
5
 
3
, Shigeru Makita 
6
 
3
, Kazuto Omiya 
7
 
3
, Yuko Kato 
8
 
3
, Hitoshi Adachi 
9
 
3
, Masatoshi Nagayama 
10
 
3
, Yoshihiro J Akashi 
11
; Committee on Exercise Prescription for Patients (CEPP) Members

Affiliations

Item in Clipboard

Kohei Ashikaga et al.


Heart Vessels.


.

Abstract

Circulatory power (CP) and ventilatory power (VP), obtained by cardiopulmonary exercise testing (CPX), have been suggested to be excellent prognostic markers for heart failure. However, the normal values of these parameters in healthy Japanese populations remain unknown; thus, we aimed to investigate these values in such a population. A total of 391 healthy Japanese participants, 20-78 years of age, underwent CPX with a cycle ergometer with ramp protocols. Systolic blood pressure (SBP), heart rate, oxygen uptake ([Formula: see text]O2) at peak exercise, and the slope of minute ventilation ([Formula: see text]E) versus carbon dioxide ([Formula: see text]CO2) ([Formula: see text]E vs. [Formula: see text]CO2 slope) were measured. CP was calculated by multiplying the peak [Formula: see text]O2 and SBP values, and VP was calculated by dividing the peak SBP value by the [Formula: see text]E versus [Formula: see text]CO2 slope. For males and females, the average CP values were 6119 ± 1280 (mean ± standard deviation) and 4775 ± 914 mmHg·mL/min/kg, respectively (p < 0.001). The average VP values for males and females were 8.0 ± 1.3 and 6.9 ± 1.3 mmHg (p < 0.001). CP decreased with age in both sexes. VP increased with age in females, with no significant change in males. We calculated the normal values for CP and VP in a healthy Japanese population. The results can contribute to the evaluation of patients’ CPX results as a reference.


Keywords:

Cardiac power; Cardiopulmonary exercise test; Circulatory power; Standard values; Ventilatory power.

References

    1. Keteyian SJ, Patel M, Kraus WE, Brawner CA, McConnell TR, Piña IL, Leifer ES, Fleg JL, Blackburn G, Fonarow GC, Chase PJ, Piner L, Vest M, O’Connor CM, Ehrman JK, Walsh MN, Ewald G, Bensimhon D, Russell SD, Investigators HF-ACTION (2016) Variables measured during cardiopulmonary exercise testing as predictors of mortality in chronic systolic heart failure. J Am Coll Cardiol 67:780–789

      –

      DOI

    1. Guazzi M, Myers J, Arena R (2005) Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure. J Am Coll Cardiol 46:1883–1890

      –

      DOI

    1. Arena R, Myers J, Aslam SS, Varughese EB, Peberdy MA (2004) Peak VO2 and VE/VCO2 slope in patients with heart failure: a prognostic comparison. Am Heart J 147:354–360

      –

      DOI

    1. Paolillo S, Veglia F, Salvioni E, Corrà U, Piepoli M, Lagioia R, Limongelli G, Sinagra G, Cattadori G, Scardovi AB, Metra M, Senni M, Bonomi A, Scrutinio D, Raimondo R, Emdin M, Magrì D, Parati G, Re F, Cicoira M, Minà C, Correale M, Frigerio M, Bussotti M, Battaia E, Guazzi M, Badagliacca R, Di Lenarda A, Maggioni A, Passino C, Sciomer S, Pacileo G, Mapelli M, Vignati C, Clemenza F, Binno S, Lombardi C, Filardi PP, Agostoni P, MECKI Score Research Group (2019) Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years. Eur J Heart Fail 21:208–217

    1. Chua TP, Ponikowski P, Harrington D, Anker SD, Webb-Peploe K, Clark AL, Poole-Wilson PA, Coats AJS (1997) Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol 29:1585–1590

      –

      DOI



Source link

Back to top button