Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder leading to liver disease and chronic obstructive pulmonary disease (COPD). A study analyzed AATD individuals with and without COPD to characterize its effects on liver disease and gene expression. Liver tissues of AATD individuals with COPD showed upregulation of genes related to fibrosis, extracellular matrix remodeling, collagen deposition, hepatocellular damage, and inflammation. The study suggests a relationship between COPD and liver disease in AATD patients and highlights the importance of addressing lung impairment and inflammation to manage AATD-related liver disease. The findings were published in the Journal of Clinical and Translational Hepatology.
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Investigating the relationship between COPD and liver disease in alpha-1 antitrypsin deficiency
