A study examined the harm-to-benefit ratio of colorectal cancer (CRC) screening based on fecal hemoglobin (f-Hb) concentrations in previous negative fecal immunochemical tests (FITs). The study found that individuals with no detectable f-Hb in previously negative FITs had a higher harm-to-benefit ratio for screening, suggesting less intensive screening for this population. The study included data from the Dutch CRC screening program and found that the number needed to screen (NNS) and number needed to scope (NNSc) to detect CRC or advanced adenoma were higher for individuals with no history of detectable f-Hb. This suggests a better balance between harms and benefits with less intensive screening for low-risk individuals.
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Harm-to-benefit ratio of FIT screening higher for those with no history of detectable blood
