Scientists have identified a novel major risk gene, LAG3, associated with autoimmune thyroid disease (AITD). This gene variant, found in Icelandic and Finnish populations, reduces the expression of LAG-3 protein in immune cells, leading to a higher risk of AITD. The study, published in Nature Communications, highlights the importance of a multiomics approach in identifying potential drug targets and safety concerns for autoimmune diseases. The findings shed light on the pathogenesis of AITD and the potential impact on immune checkpoint inhibitor therapy for cancer. Further research is needed to understand the functional significance of this risk variant and its implications for personalized medicine.
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Scientists uncover novel major risk gene for autoimmune thyroid disease
