The article discusses the role of dAcsl enzyme in regulating systemic lipid homeostasis and lipid transport. Lipid homeostasis and interorgan lipid transport are crucial for organism development and maintenance of physiological function. Dyslipidemia, which is the disruption of lipid homeostasis, can lead to physiological disorders such as obesity, diabetes, cardiovascular diseases, and developmental defects. Research on Drosophila melanogaster, as a model for human metabolic diseases, revealed that knockdown of dAcsl enzyme led to disruptions in overall lipid metabolism, carbohydrate metabolism, and endoplasmic reticulum stress. It was also discovered that the role of ACSL4 in modulating lipoprotein content was conserved in human HepG2 cells. The study uncovers a previously uncharacterized metabolic aspect of ACSL4 in maintaining systemic lipid homeostasis and whole-body metabolism.
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Scientists reveal how dAcsl orchestrates lipid transport in Drosophila
