Weight Gain From Antidepressants Varies; Here Are Drugs With Least And Most Impact


A new study analyzed eight common antidepressants and found that bupropion leads to the least amount of weight gain compared to other medications. Patients who use bupropion have a 15-20% lower risk of weight gain compared to those who use sertraline, the most common medication. Antidepressants can have a significant impact on weight gain, which can affect long-term metabolic health and discourage patients from continuing treatment. The study suggests that specific antidepressant medications may affect weight differently, and patients and their clinicians should consider weight gain when selecting a medication. The research was conducted by the Harvard Pilgrim Health Care Institute and included data from 183,118 adults.

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