Significant Benefit With Liver Transplantation in ACLF


Liver transplantation improves survival in patients with acute-on-chronic liver failure (ACLF), with 3-month post-transplantation mortality rates in ACLF grades 2 and 3 similar to those with decompensated cirrhosis. The CHANCE study highlights the inadequacy of current transplant allocation criteria for ACLF patients, leading to excess mortality on the waitlist. MELD scores do not account for the risk of death due to multiorgan failure in ACLF patients. The study aims to compare outcomes after liver transplantation in ACLF patients and those with decompensated cirrhosis. The results underscore the need for increased access to liver transplantation and changes in organ allocation criteria.

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