Growth factors linked to stem cell aging in bone marrow study

A study conducted at the Jackson Laboratory focused on hematopoietic stem cells in the bone marrow of middle-aged mice, revealing variations in cell aging among individuals. The research found that the decline in growth factors produced by surrounding mesenchymal stromal cells correlated with age-associated changes in stem cells. This study, which looked at individual mice instead of pooled stem cells, suggests that variations in stem cell aging may play a role in health outcomes. The findings could have implications for understanding aging-related diseases, such as blood cancers, in both mice and humans.

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