Study reveals association between ribosomal DNA copy number and disease risk

Ribosomal DNA (rDNA) is found in multiple copies in the genome and has not been previously analyzed in genetic studies. A new study of 500,000 individuals reveals that those with more rDNA copies are more prone to inflammation and diseases. This study, led by researchers from Queen Mary University of London and The University of Queensland, utilized whole genome sequencing to uncover genetic links to diseases in repetitive genome regions like rDNA. The findings show that rDNA copy number is associated with markers of inflammation and kidney function, offering new insights for preventative diagnostics and therapies. This research emphasizes the importance of analyzing the entire genome for a better understanding of health factors and disease risks.

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