Sex Hormone Ratios Tied to Metabolic Syndrome Risk

A study found that elevated free estradiol index (FEI) is strongly linked to metabolic and inflammatory markers in men of all ages and older women, while a higher free androgen index (FAI) is associated with similar markers in women younger than 50 years. The research, based on data from over 9,000 adults, suggests that imbalances in sex hormones may be markers for metabolic syndrome and inflammation. Elevated FEI levels were associated with increased risk of metabolic syndrome and inflammation in both men and women, depending on their age. Regular evaluation of sex hormone ratios could be important for assessing cardiovascular disease risk. The study was conducted by Pallavi Dubey and published in Frontiers in Endocrinology.

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