Researchers develop innovative platform for modeling human muscle diseases in worms

Researchers from Bar-Ilan University and Sheba Medical Center have created a new platform using C. elegans worms to model human muscle diseases, such as Duchenne muscular dystrophy, without genetic modifications. They harvested extracellular vesicles from patients with the disease and transferred them to the worms, resulting in muscle atrophy similar to human symptoms. This innovative approach allows for versatile, scalable disease modeling and drug screening. The study, published in Disease Models & Mechanisms, shows the potential of this platform to study various diseases. This new technique utilizes extracellular vesicles from patient blood samples to transfer disease information across species.

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