New insights into how exercise may help prevent or slow cognitive decline during aging

New research in Aging Cell shows that exercise may help prevent or slow cognitive decline during aging. The study involved assessing gene expression in brain cells of mice and found that exercise can revert gene patterns in aged microglia cells to those of young cells. Depleting microglia revealed their role in the stimulatory effects of exercise on new neuron formation in the hippocampus. Access to a running wheel prevented T cell presence in the hippocampus during aging. The study highlights the rejuvenating effects of exercise on brain immune cells and underscores the importance of tailored exercise programs for the elderly.

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