The Future of Major Depressive Disorder Treatments

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In the last 20 years, treatment options for major depressive disorder have significantly improved. Advances in evidence-based treatment have led to the development of more selective antidepressants with fewer side effects. Psychotherapy combined with drug therapy, such as newer medications like citalopram and escitalopram, is found to be the most effective. Newer treatments like ketamine therapy, psychedelics, transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS) are showing promising results in treating severe, treatment-resistant depression. Emerging technology is moving towards minimal or noninvasive DBS, which may be available in 5-10 years. These advancements offer hope for better treatment outcomes in the future.

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