New synapse type discovered through spatial proteomics

Researchers have developed a new super-resolution imaging method called SUM-PAINT, which allows for fast and detailed visualization of proteins in 3D neuronal cells. This technique has revealed a previously unknown type of synapse and has the potential to revolutionize the study of protein organization and neurological disorders. The team created a detailed atlas of neuronal cells with single-molecule resolution for 30 different proteins and used machine learning for further analysis. The method could lead to new therapeutic approaches for diseases like Parkinson’s and Alzheimer’s. SUM-PAINT is easy to use and provides a comprehensive view of protein interactions at the molecular level.

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