Medication Strategies for Treatment-Resistant Depression

For individuals with treatment-resistant depression, it may take time to find the right medication that works. There are over two dozen safe and effective antidepressants available, but doctors cannot predict how individuals will respond to each one due to various factors such as genetics and stressors. Strategies for treatment-resistant depression include ensuring medication adherence, giving current medication more time to work, adjusting the medication dose, switching to a different antidepressant, or adding another medication to the current one. Pharmacogenetic testing can also provide insights into how the body metabolizes medication. It may be necessary to try multiple medications before finding the right one, but with perseverance and communication with a doctor, effective treatment can be found.

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