GLP-1RAs associated with increased residual gastric content, despite preprocedural fasting

A study published in JAMA Surgery found that fasted patients taking once-weekly glucagon-like peptide-1 receptor agonists (GLP-1RAs) before elective procedures under anesthesia had a higher prevalence of increased residual gastric content, increasing their risk for aspiration. The study included 124 adult patients, with 62 taking GLP-1RAs. Results showed a 30.5% higher prevalence of increased residual gastric content in patients taking GLP-1RAs compared to those who did not. The study suggests the need for further research to determine safe discontinuation intervals and preprocedural fasting times for patients taking GLP-1RAs before elective procedures under anesthesia.

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