Air Pollution and Alzheimer Disease Pathology: What’s the Link?

Traffic-related pollution is linked to increased neuritic plaques in Alzheimer’s patients, especially in those without APOE ε4 alleles. Exposure to PM2.5 has been associated with dementia and cognitive decline. A study at the Emory Goizueta Alzheimer’s Disease Research Center found a significant association between PM2.5 and CERAD scores. The study had limitations, including a small sample size of mainly White, educated participants. More research is needed to establish causality and explore the relationship between PM2.5 and other dementia-related pathologies. The study suggests a potential link between air pollution and Alzheimer’s disease, particularly in individuals without specific genetic risk factors.

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