Study suggests patients with severe long COVID present with variable symptoms, do not cluster in relation to organs affected or immunological states

A new preprint on medRxiv summarizes a study called “Restrained memory CD8+ T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID” which discusses associations found in long COVID. The study points to evidence indicating a link between persistent viral RNA and elevated antibody responses. The study focused on patients with mild to moderate COVID-19 who developed severe long COVID, finding that these patients had no common set of symptoms, signs of organ damage, or characteristic immunological profile. They determined that individuals who failed to mount an expanded memory CD8+ T cell response developed a viral reservoir with persistent antigen, leading to long-term elevation of anti-SARS-CoV-2 IgG.

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