Screening and Treatment Reduce Breast Cancer Mortality

Breast cancer mortality in the United States decreased significantly between 1975 and 2019, attributed to improved screening and treatments, particularly for hormone receptor-positive cancers. Therapeutic advances, such as 30 new anticancer drugs approved between 2010 and 2020, played a crucial role in this decline. Models developed by the Cancer Intervention and Surveillance Modeling Network (CISNET) quantified the relative associations between breast cancer screening, treatment for different stages, and improvement in breast cancer mortality. The study found a 58% reduction in mortality, with 47% attributed to treatments for stages I-III, 29% to treatments for metastatic forms, and 25% to screening. However, the accuracy of simulations relies on baseline data precision and does not consider potential disparities or intervention costs.

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