Rare gene mutations in hereditary Alzheimer’s disease disrupt amyloid production, study shows

A University of Kansas study on rare gene mutations causing hereditary Alzheimer’s disease found that disruptions in the production of amyloid, a protein found in plaques in the brain, can lead to the loss of nerve cell connections. The research focused on rare inherited mutations that trigger Alzheimer’s disease at a younger age, with a 50% chance of inheritance. These mutations show similar pathology to the common form of Alzheimer’s. The study, led by Michael Wolfe, suggests potential new therapies that target restarting the stalled production of amyloid. The findings could lead to a better understanding of Alzheimer’s and the development of improved treatments.

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