Macular neovascularization changes persist in AMD, even with long-term anti-VEGF therapy

The article discusses a study that found that macular neovascularization (MNV) and complete retinal pigment epithelium (RPE) and outer retina atrophy (cRORA) continue to grow even with frequent anti-VEGF treatment for neovascular age-related macular degeneration. The growth of MNV was observed to be continuous, while cRORA developed in association with increasing MNV size. Researchers also noted that while MNV may play a nourishing role to the RPE and photoreceptors up to a point, larger complexes lose this ability as they mature. The study was limited in its analysis, as the type of anti-VEGF agents used by patients varied, and further investigation is needed to see if these changes hold true on individualized treatments.

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