Increased risk of autoimmune disease after Cushing’s disease remission

A study found that patients who achieved remission from Cushing’s disease after pituitary surgery were more likely to develop new-onset autoimmune disease within 3 years. This was compared to those with surgically treated nonfunctioning pituitary adenomas. Researchers found a cumulative incidence of 10.4 percent of new autoimmune diseases in the Cushing’s disease group. They suggest that postoperative adrenal insufficiency and lower cortisol levels in the Cushing’s disease group might have contributed to the development of autoimmune diseases. The findings have implications for understanding the natural history of autoimmune disease and its relationship to cortisol fluctuations. The study was published in the Annals of Internal Medicine.

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