Elusive immune cells dwelling in ‘hidden niches’ of the bone marrow may be key to SARS-CoV-2 vaccination

Immunologists have limited knowledge of the long-lived plasma cells (LLPCs) that produce antibodies in response to SARS-CoV-2 vaccination. These cells reside in the bone marrow and are challenging to study in humans due to their hidden niche. A new research technique developed by scientists has shed light on how LLPCs respond to SARS-CoV-2 vaccination and the cascade of events in the bone marrow. The study found that two doses of adjuvanted SARS-CoV-2 spike protein vaccine can induce spike protein-specific LLPC reservoirs in nonhuman primates. This technique provides valuable insights into vaccine efficacy and immune responses. Further research is needed to understand the seeding and maintenance of LLPCs.

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