Chronic inflammation and inactivity may affect age-related changes in gene and protein expression in skeletal muscle

New research suggests that age-related changes in gene and protein expression in the skeletal muscles of older individuals may be influenced more by physical inactivity and chronic inflammation rather than primary aging processes. The study found that physical inactivity and chronic inflammation are the most important drivers of secondary aging, which are changes caused by extrinsic factors such as diseases or poor health practices. Conversely, primary aging was found to be related to only a small number of genes. The study’s findings may be important for developing approaches to slow aging by regulating the expression of these genes.

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