Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ

Breast cancer screening has reduced breast cancer deaths, but has led to an increase in non-screen detected ductal carcinoma in situ (DCIS). A study by Mannu and colleagues found that women with non-screen detected DCIS were 1.37 times more likely to die from breast cancer than those with screen-detected DCIS. Those diagnosed at a younger age had the greatest increase in mortality rates. The route of detection and choice of treatment for DCIS did not seem to affect mortality in non-screened women. This study highlights the importance of longer follow-up after a DCIS diagnosis and the need for more personalized, risk-based screening strategies to address the ongoing debate about overdiagnosis and overtreatment of DCIS.

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