Elevated Lipoprotein (a) Increases Risk for PAD, AAA, Major Adverse Limb Events

A study published in the Journal of the American College of Cardiology found that high levels of Lipoprotein(a) (Lp[a]) are associated with an increased risk for peripheral artery disease (PAD), abdominal aortic aneurysm (AAA), and major adverse limb events (MALE). The study analyzed data from the Copenhagen General Population Study and the Copenhagen City Heart Study, and found that individuals with higher Lp(a) levels were at elevated risk for hospital-diagnosed PAD and AAA. The study also identified genetic factors associated with increased risk for these conditions. The authors suggest that future Lp(a)-lowering therapies could be beneficial for preventing PAD, AAA, and MALE.

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