Warfarin Tied to Benefit After SAVR

A study using claims data from commercially insured and Medicare Advantage enrollees found that postoperative anticoagulation early after surgical aortic valve replacement (SAVR) with a bioprosthetic valve was associated with improved survival and a lower risk for thromboembolic events. The study included 10,589 patients who underwent SAVR and found that warfarin use early postoperatively was associated with reduced risk for overall mortality and thromboembolic events, but increased risk for major bleeding. The study suggests that anticoagulant treatment early after surgery may be beneficial despite concerns about bleeding. However, the study has some limitations and the results may not be generalizable to the entire US population.

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