Thyrotoxicosis linked to risk for incident cognitive disorder

A recent study published in JAMA Internal Medicine found that older adults exposed to a low thyrotropin (TSH) level from either endogenous or exogenous thyrotoxicosis are associated with a higher risk for incident cognitive disorder. The study involved 65,931 patients over the age of 65, and the exposure variable was low TSH level due to endogenous thyrotoxicosis, exogenous thyrotoxicosis, or unknown cause. The researchers found that thyrotoxicosis was associated with an increased risk for cognitive disorders, and exogenous thyrotoxicosis remained a significant risk factor. These findings suggest that thyroid hormone excess could lead to an increased risk of cognitive disorders, particularly in older adults.

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