Predicting Alzheimer’s dementia in oldest of the old

A new study indicates that the severity of amyloid deposition in the brain, rather than just age, may be a key factor in determining who will benefit from new anti-amyloid therapies in order to delay the progression of Alzheimer’s disease. Researchers found that the baseline amyloid burden and overall brain health may be stronger predictors of those likely to progress to Alzheimer’s compared to age. The study examined a group of elderly individuals who were cognitively unimpaired at the start of the study to better understand the relationship between amyloid deposition and dementia. The findings suggest that understanding the presence of pathologies like small vessel disease is critical for future prevention therapies.

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