Pancreatic enzymatic replacement therapy improves maladaptive behavior in preschool children with autism, finds study

A study published in JAMA Network Open demonstrated improvement in maladaptive behaviors, such as irritability, in preschool children with autism spectrum disorder (ASD) through the use of high-protease pancreatic replacement therapy. The therapy was found to be associated with minimal side effects and led to significant decreases in symptoms of irritability, hyperactivity/noncompliance, and inappropriate speech, as well as lethargy/social withdrawal in the treated children. This study suggests that pancreatic enzymatic replacement therapy can enhance the supply of essential amino acids necessary for the synthesis of neurotransmitters, resulting in improved behavioral function in preschoolers with ASD.

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