Natural experiments with sildenafil and stiffness

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The author, Benjamin Woolf, recounts how he went into multiple organ failure and was hospitalized for nearly 100 days after being diagnosed with chronic thrombotic pulmonary hypertension and receiving treatment with macitentan and sildenafil. During his recovery, he became curious about the long-term effects of sildenafil, a medication commonly prescribed to treat erectile dysfunction. He acknowledges the limitations of personally experimenting with the drug and instead considers the use of drug target mendelian randomization to study the consequences of long-term exposure to sildenafil. This approach aligns with his previous work applying mendelian randomization to study the intergenerational effects of exposures on health outcomes. The linked article in the Christmas issue explores the potential effects of PDE5 inhibitors like sildenafil.

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