Journal Club: WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome

ME/CFS is a syndrome that affects millions of people worldwide, causing crushing fatigue, muscle aches, and difficulty sleeping, among other symptoms. While the cause of this illness has been a mystery, recent research has discovered a potential link between ME/CFS and a protein called WASF3. The study found that some ME/CFS patients have higher levels of WASF3 in their mitochondria, which interferes with the production of energy from oxygen and glucose. When the production of WASF3 was reduced in cell samples, the cells were able to produce energy more efficiently. This discovery could potentially lead to new treatments for ME/CFS.

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