In Nonvalvular Atrial Fibrillation, a History of Cancer Affects Stroke, Bleeding Risk

A study published in the Journal of the American Heart Association found that patients with nonvalvular atrial fibrillation (NVAF) and certain types of cancer have increased risks of stroke and bleeding. The risk for thromboembolic disease and arterial thromboembolism is associated with most cancer types, along with some chemotherapy regimens. The study assessed data from over 11,000 patients with NVAF and a history of breast, prostate, colorectal, lung, or hematologic cancers between 2009 and 2019. Patients with cancer had higher CHA2DS2-VASc and HAS-BLED scores, indicating increased risk for stroke and bleeding. Breast, colorectal, prostate, lung, and hematologic cancers were associated with significantly increased risks of stroke and bleeding.

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