Binge drinking, genetic predisposition linked to sixfold higher risk for cirrhosis

A study found that heavy binge drinking and high polygenic risk score were associated with a sixfold higher relative excess risk for alcohol-related cirrhosis. Daily alcohol consumption and genetic factors were found to be associated with the risk for developing liver disease. The study analyzed data from over 300,000 participants and concluded that drinking pattern is a better indicator of liver disease risk than volume alone. The risk of alcohol-related cirrhosis increased monotonically with rising polygenic risk score. Diabetes mellitus status significantly increased the risk for liver disease, and the study suggested that genetic information could allow for a more accurate prediction of risk.

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