A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study

. 2023 Jan 5;9(1):e12829.

doi: 10.1016/j.heliyon.2023.e12829.

eCollection 2023 Jan.


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Chenjing Wang et al.




Curcumin, from the rhizome of turmeric (Curcuma longa L.), has a wide variety of biological activities. Unfortunately, its poor water-solubility greatly limits its bioavailability. The purpose of this study was to evaluate CUMINUP60®, a novel preparation utilizing a solvent-free, co-grinding method designed to improve curcumin’s bioavailability. We performed a single-center crossover experiment to compare the new product with standard 95% curcumin in the blood plasma of twelve healthy adults (10 males, 2 females). Total bioavailability of curcumin and its sulfate and glucuronide conjugates from the test product, measured by their areas under the curve over 12 h (AUC0-T), showed a combined increase of 178-fold over standard curcumin and its conjugates from the reference product. The new product represents a significant improvement for providing greater bioavailability of curcumin, as compared with several other branded preparations. It therefore has broad applications for preparing curcumin as a more effective health ingredient in functional foods, beverages, and nutraceuticals.


CUMINUP60®; Curcumin; Oral bioavailability; Pharmacokinetics.

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as a potential competing interest: CUMINUP60® is the registered trademark name of Chenland Nutritionals, Inc., for the test product used in the present study. Chenland Nutritionals, Inc., had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.


Fig. 1

Plasma levels of free curcumin (a), curcumin sulfate (b), and curcumin glucuronide (c) after a single dose of the study products. Mean ± SEM. (■ = test product; ▲ = reference product).


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