A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study

. 2023 Jan 5;9(1):e12829.

doi: 10.1016/j.heliyon.2023.e12829.

eCollection 2023 Jan.

Chenjing Wang¹, Xin Jiang¹, Xiaolei Zhang¹, Yi Xu¹, Li Li², Xin Li², Shanglong Wang², Ping Shi¹, Xiaomeng Gao¹, Zimin Liu^{2

3}, W Dennis Clark³, Yu Cao¹

Affiliations

¹ Phase I Clinical Research Center, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Shinan District, Qingdao City, Shandong Province 266003, China.
² Chenland Research Institute, 333 Songling Road, Laoshan District, Qingdao City, Shandong Province 266104, China.
³ Chenland Nutritionals, Inc., 3 Park Plaza, Suite 0410, Irvine, CA 92614, USA.

Item in Clipboard

Chenjing Wang et al.

Heliyon.

2023.

. 2023 Jan 5;9(1):e12829.

doi: 10.1016/j.heliyon.2023.e12829.

eCollection 2023 Jan.

Authors

Chenjing Wang¹, Xin Jiang¹, Xiaolei Zhang¹, Yi Xu¹, Li Li², Xin Li², Shanglong Wang², Ping Shi¹, Xiaomeng Gao¹, Zimin Liu^{2

3}, W Dennis Clark³, Yu Cao¹

Affiliations

¹ Phase I Clinical Research Center, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Shinan District, Qingdao City, Shandong Province 266003, China.
² Chenland Research Institute, 333 Songling Road, Laoshan District, Qingdao City, Shandong Province 266104, China.
³ Chenland Nutritionals, Inc., 3 Park Plaza, Suite 0410, Irvine, CA 92614, USA.

Item in Clipboard

Abstract

Curcumin, from the rhizome of turmeric (Curcuma longa L.), has a wide variety of biological activities. Unfortunately, its poor water-solubility greatly limits its bioavailability. The purpose of this study was to evaluate CUMINUP60®, a novel preparation utilizing a solvent-free, co-grinding method designed to improve curcumin’s bioavailability. We performed a single-center crossover experiment to compare the new product with standard 95% curcumin in the blood plasma of twelve healthy adults (10 males, 2 females). Total bioavailability of curcumin and its sulfate and glucuronide conjugates from the test product, measured by their areas under the curve over 12 h (AUC_0-T), showed a combined increase of 178-fold over standard curcumin and its conjugates from the reference product. The new product represents a significant improvement for providing greater bioavailability of curcumin, as compared with several other branded preparations. It therefore has broad applications for preparing curcumin as a more effective health ingredient in functional foods, beverages, and nutraceuticals.

Keywords:

CUMINUP60®; Curcumin; Oral bioavailability; Pharmacokinetics.

Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as a potential competing interest: CUMINUP60® is the registered trademark name of Chenland Nutritionals, Inc., for the test product used in the present study. Chenland Nutritionals, Inc., had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Fig. 1

Plasma levels of free curcumin (a), curcumin sulfate (b), and curcumin glucuronide (c) after a single dose of the study products. Mean ± SEM. (■ = test product; ▲ = reference product).

References

1. Ak T., Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chem. Biol. Interact. 2008;174(1):27–37. doi: 10.1016/j.cbi.2008.05.003.
  
  –
  
  DOI
  
  –
  
  PubMed
1. Amalraj A., Pius A., Gopi S., Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – a review. J. Tradit. Complement. Med. 2016;7(2):205–233. doi: 10.1016/j.jtcme.2016.05.005.
  
  –
  
  DOI
  
  –
  
  PMC
  
  –
  
  PubMed
1. Jurenka J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Med. Rev. 2009;14(2):141–153. PMID: 19594223.
  
  –
  
  PubMed
1. Kishimoto A., Imaizumi A., Wada H., Yamakage H., Satoh-Asahara N., Hashimoto T., Hasegawa K. Newly developed highly bioavailable curcumin formulation, curcuRougeTM, reduces neutrophil/lymphocyte ratio in the elderly: a double-blind, placebo-controlled clinical trial. J. Nutr. Sci. Vitaminol. 2021;67(4):249–252. doi: 10.3177/jnsv.67.249. PMID: 34471000.
  
  –
  
  DOI
  
  –
  
  PubMed
1. Kocaadam B., Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017;57(13):2889–2895. doi: 10.1080/10408398.2015.1077195.
  
  –
  
  DOI
  
  –
  
  PubMed

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