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Pathological features of glial cells and motor neurons in the anterior horn of the spinal cord in sporadic ALS using ADAR2 conditional knockout mice


    • Kawahara Y.
    • Ito K.
    • Sun H.
    • Aizawa H.
    • Kanazawa I.
    • Kwak S.

    Glutamate receptors: RNA editing and death of motor neurons.

    Nature. 2004; 427: 801https://doi.org/10.1038/427801a

    View
    in Article

    • Hideyama T.
    • Yamashita T.
    • Aizawa H.
    • Tsuji S.
    • Kakita A.
    • Takahashi H.
    • Kwak S.

    Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons.

    Neurobiol. Dis. 2012; 45: 1121-1128https://doi.org/10.1016/j.nbd.2011.12.033

    View
    in Article

    • Higuchi M.
    • Single F.
    • Kohler M.
    • Sommer B.
    • Sprengel R.
    • Seeburg P.H.

    RNA editing of AMPA receptor subunit GluR-B: a base- paired intron-exon structure determines position and efficiency.

    Cell. 1993; 75: 1361-1370https://doi.org/10.1016/0092-8674(93)90622-w

    View
    in Article

    • Higuchi M.
    • Maas S.
    • Single F.N.
    • Hartner J.
    • Rozov A.
    • Burnashev N.
    • Feldmeyer D.
    • Sprengel R.
    • Seeburg P.H.

    Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2.

    Nature. 2000; 406: 78-81https://doi.org/10.1038/35017558

    View
    in Article

    • Hideyama T.
    • Yamashita T.
    • Suzuki T.
    • Tsuji S.
    • Higuchi M.
    • Seeburg P.H.
    • Takahashi R.
    • Misawa H.
    • Kwak S.

    Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2.

    J. Neurosci. 2010; 30: 11917-11925https://doi.org/10.1523/JNEUROSCI.2021-10.2010

    View
    in Article

    • Hideyama T.
    • Kwak S.

    When does ALS start? ADAR2-GluA2 hypothesis for the etiology of sporadic ALS.

    Front. Mol. Neurosci. 2011; 4: 33https://doi.org/10.3389/fnmol.2011.00033

    View
    in Article

    • Aizawa H.
    • Sawada J.
    • Hideyama T.
    • Yamashita T.
    • Katayama T.
    • Hasebe N.
    • Kimura T.
    • Yahara O.
    • Kwak S.

    TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2.

    Acta Neuropathol. 2010; 120: 75-84https://doi.org/10.1007/s00401-010-0678-x

    View
    in Article

    • Hideyama T.
    • Teramoto S.
    • Hachiga K.
    • Yamashita T.
    • Kwak S.

    Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons.

    PLoS One. 2012; 7e43469https://doi.org/10.1371/journal.pone.0043469

    View
    in Article

    • Lee R.H.
    • Heckman C.J.

    Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents.

    J. Neurophysiol. 1998; 80: 583-593https://doi.org/10.1152/jn.1998.80.2.583

    View
    in Article

    • Lee R.H.
    • Heckman C.J.

    Bistability in spinal motoneurons in vivo: systematic variations in rhythmic firing patterns.

    J. Neurophysiol. 1998; 80: 572-582https://doi.org/10.1152/jn.1998.80.2.572

    View
    in Article

    • Cotel F.
    • Antri M.
    • Barthe J.Y.
    • Orsal D.

    Identified ankle extensor and flexor motoneurons display different firing profiles in the neonatal rat.

    J. Neurosci. 2009; 29: 2748-2753https://doi.org/10.1523/JNEUROSCI.3462-08.2009

    View
    in Article

    • Dengler R.
    • Konstanzer A.
    • Kuther G.
    • Hesse S.
    • Wolf W.
    • Struppler A.

    Amyotrophic lateral sclerosis: macro-EMG and twitch forces of single motor units.

    Muscle Nerve. 1990; 13: 545-550https://doi.org/10.1002/mus.880130612

    View
    in Article

    • Sturrock R.R.

    Loss of neurons from the motor nucleus of the facial nerve in the ageing mouse brain.

    J. Anat. 1988; 160: 189-194

    View
    in Article

    • Sturrock R.R.

    Stability of motor neuron number in the oculomotor and trochlear nuclei of the ageing mouse brain.

    J. Anat. 1991; 174: 125-129

    View
    in Article

    • Misawa H.
    • Nakata K.
    • Toda K.
    • Matsuura J.
    • Oda Y.
    • Inoue H.
    • Tateno M.
    • Takahashi R.

    VAChT-Cre.Fast and VAChT- Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset.

    Genesis. 2003; 37: 44-50https://doi.org/10.1002/gene.10224

    View
    in Article

    • Festing M.F.
    • Altman D.G.

    Guidelines for the design and statistical analysis of experiments using laboratory animals.

    ILAR J. 2002; 43: 244-258https://doi.org/10.1093/ilar.43.4.244

    View
    in Article

    • McHanwell S.
    • Biscoe T.J.

    The localization of motoneurons supplying the hindlimb muscles of the mouse.

    Philos. Trans. R. Soc. Lond .B. Biol. Sci. 1981; 293: 477-508https://doi.org/10.1098/rstb.1981.0082

    View
    in Article

    • McHanwell S.
    • Biscoe T.J.

    The sizes of motoneurons supplying hindlimb muscles in the mouse.

    Proc. R. Soc. Lond. B Biol. Sci. 1981; 213: 201-216https://doi.org/10.1098/rspb.1981.0062

    View
    in Article

    • Burke R.E.
    • Levine D.N.
    • Tsairis P.
    • Zajac III, F.E.

    Physiological types and histochemical profiles in motor units of the cat gastrocnemius.

    J. Physiol. 1973; 234: 723-748https://doi.org/10.1113/jphysiol.1973.sp010369

    View
    in Article

    • Frey D.
    • Schneider C.
    • Xu L.
    • Borg J.
    • Spooren W.
    • Caroni P.

    Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases.

    J. Neurosci. 2000; 20: 2534-2542https://doi.org/10.1523/JNEUROSCI.20-07-02534.2000

    View
    in Article

    • Pun S.
    • Santos A.F.
    • Saxena S.
    • Xu L.
    • Caroni P.

    Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF.

    Nat. Neurosci. 2006; 9: 408-419https://doi.org/10.1038/nn1653

    View
    in Article

    • Morisaki Y.
    • Niikura M.
    • Watanabe M.
    • Onishi K.
    • Tanabe S.
    • Moriwaki Y.
    • Okuda T.
    • Ohara S.
    • Murayama S.
    • Takao M.
    • Uchida S.
    • Yamanaka K.
    • Misawa H.

    Selective expression of Osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by Matrix Metalloproteinase-9.

    Sci. Rep. 2006; 6: 27354https://doi.org/10.1038/srep27354

    View
    in Article

    • Kaplan A.
    • Spiller K.J.
    • Towne C.
    • Kanning K.C.
    • Choe G.T.
    • Geber A.
    • Akay T.
    • Aebischer P.
    • Henderson C.E.

    Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration.

    Neuron. 2014; 81: 333-348https://doi.org/10.1016/j.neuron.2013.12.009

    View
    in Article

    • Hashizume K.
    • Kanda K.
    • Burke R.E.

    Medial gastrocnemius motor nucleus in the rat: age-related changes in the number and size of motoneurons.

    J. Comp. Neurol. 1988; 269: 425-430https://doi.org/10.1002/cne.902690309

    View
    in Article

    • Hirofuji C.
    • Ishihara A.
    • Roy R.R.
    • Itoh K.
    • Itoh M.
    • Edgerton V.R.
    • Katsuta S.

    SDH activity and cell size of tibialis anterior motoneurons and muscle fibers in SAMP6.

    NeuroReport. 2000; 11: 823-828https://doi.org/10.1097/00001756-200003200-00033

    View
    in Article

    • Saxena S.
    • Cabuy E.
    • Caroni P.

    A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice.

    Nat. Neurosci. 2009; 12: 627-636https://doi.org/10.1038/nn.2297

    View
    in Article

    • Kanda K.
    • Hashizume K.

    Changes in properties of the medial gastrocnemius motor units in aging rats.

    J. Neurophysiol. 1989; 61: 737-746https://doi.org/10.1152/jn.1989.61.4.737

    View
    in Article

    • Kadhiresan V.A.
    • Hassett C.A.
    • Faulkner J.A.

    Properties of single motor units in medial gastrocnemius muscles of adult and old rats.

    J. Physiol. 1996; 493: 543-552https://doi.org/10.1113/jphysiol.1996.sp021402

    View
    in Article

    • Lasiene J.
    • Yamanaka K.

    Glial cells in amyotrophic lateral sclerosis.

    Neurol. Res. Int. 2011; 2011718987https://doi.org/10.1155/2011/718987

    View
    in Article

    • Yamanaka K.
    • Chun S.J.
    • Boillee S.
    • Fujimori-Tonou N.
    • Yamashita H.
    • Gutmann D.H.
    • Takahashi R.
    • Misawa H.
    • Cleveland D.W.

    Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis.

    Nat. Neurosci. 2008; 11: 251-253https://doi.org/10.1038/nn2047

    View
    in Article

    • Iyer A.K.
    • Jones K.J.
    • Sanders V.M.
    • Walker C.L.

    Temporospatial analysis and new players in the immunology of amyotrophic lateral sclerosis.

    Int. J. Mol. Sci. 2018; 19: 631https://doi.org/10.3390/ijms19020631

    View
    in Article

    • Kanning K.C.
    • Kaplan A.
    • Henderson C.E.

    Motor neuron diversity in development and disease.

    Annu. Rev. Neurosci. 2010; 33: 409-440https://doi.org/10.1146/annurev.neuro.051508.135722

    View
    in Article

    • Nikoletopoulou V.
    • Tavernarakis N.

    Calcium homeostasis in aging neurons.

    Front. Genet. 2012; 3: 200https://doi.org/10.3389/fgene.2012.00200

    View
    in Article

    • Mattson M.P.

    Calcium and neurodegeneration.

    Aging Cell. 2007; 6: 337-350https://doi.org/10.1111/j.1474-9726.2007.00275.x

    View
    in Article

    • Bezprozvanny I.

    Calcium signaling and neurodegenerative diseases.

    Trends. Mol. Med. 2009; 15: 89-100https://doi.org/10.1016/j.molmed.2009.01.001

    View
    in Article



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