Spotlight on the December 6 Issue

Notable in Neurology This Week

This issue features an article that investigates the clinical outcomes of postendovascular thrombectomy in patients with acute stroke with cancer; another determines the cognitive outcomes of lysine reduction therapies for patients with pyridoxine-dependent epilepsy. A featured Review explores the origins of amyotrophic lateral sclerosis as either distal or cortical.

Research Articles

Cognitive-Driven Activities of Daily Living Impairment as a Predictor for Dementia in Parkinson Disease: A Longitudinal Cohort Study

Using cognitive and clinical scores and genetic and CSF biomarkers, this study showed that cognitive-associated instrumental activity of daily living (IADL) impairment in patients with Parkinson disease (PD) increased the risk of dementia. Patients with PD with cognitive and motor-driven IADL impairment are a potential target group for intervention trials.

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Association of Red Blood Cell Omega-3 Fatty Acids With MRI Markers and Cognitive Function in Midlife: The Framingham Heart Study

In this study, higher Omega-3 index was associated with larger hippocampal volumes, higher docosahexaenoic and eicosapentaenoic acid concentrations, and better abstract reasoning among middle-aged adults. These associations varied by APOE genotype. The results suggest that higher omega-3 fatty acid concentrations relate to better brain structure and cognitive function.

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Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage: Post Hoc Analysis of the ULTRA Trial

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Antifibrinolytic treatment reduces rebleeding rates after subarachnoid hemorrhage; however, its effect on clinical outcome is debated. Clinical outcome in this study did not significantly differ between patients with aneurysmal subarachnoid hemorrhage treated with tranexamic acid and those treated with standard care. Therefore, tranexamic acid treatment in patients with aneurysmal subarachnoid hemorrhage is not recommended.

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