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[Interaction of Chinese and western medicines in treatment of cardiovascular diseases]


. 2022 Oct;47(19):5121-5130.


doi: 10.19540/j.cnki.cjcmm.20220613.501.

[Article in

Chinese]

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[Article in

Chinese]

Ying Zhang et al.


Zhongguo Zhong Yao Za Zhi.


2022 Oct.

Abstract

Cardiovascular diseases are a global public health problem, and the combination of Chinese and western medicine tends to be a major solution in China. However, the complex components in traditional Chinese medicine may interact with the therapeutic western medicines for the diseases, which will lead to the herb-drug interaction(HDI). The information on the interaction can serve as a reference for the rational combination of the Chinese and western medicines in the clinical treatment of cardiovascular diseases and help avoid the occurrence of clinical safety events. However, the research on the interaction of Chinese medicine is limited as compared with that on western medicine, and no systematic review on HDI in the treatment of cardiovascular diseases is available. Therefore, this study first introduced the mechanism of HDI, then summarized the research on HDI for the commonly used drugs for cardiovascular diseases, analyzed the problems in the available studies, and put forward suggestions on the application, regulation, and research. This study aims to highlight HDI in clinical drug use and provide a reference for rational use of combination of Chinese and western medicines in the treatment of cardiovascular diseases.


Keywords:

cardiovascular disease; herb-drug interaction; pharmacokinetics.



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