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Integrin beta1 (ITGB1) as a prognostic marker in esophageal adenocarcinoma


  • Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Arnold, M., Laversanne, M., Brown, L. M., Devesa, S. S. & Bray, F. Predicting the future burden of esophageal cancer by histological subtype: International trends in incidence up to 2030. Am. J. Gastroenterol. 112(8), 1247–1255 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • van Hagen, P. et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N. Engl. J. Med. 366(22), 2074–2084 (2012).

    Article 
    PubMed 

    Google Scholar
     

  • Al-Batran, S. E. et al. Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): Results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. Lancet Oncol. 17(12), 1697–1708 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kato, K. et al. KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer. Future Oncol. 15(10), 1057–1066 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Janjigian, Y. Y. et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): A randomised, open-label, phase 3 trial. Lancet 398(10294), 27–40 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Desgrosellier, J. S. & Cheresh, D. A. Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 10(1), 9–22 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hamidi, H. & Ivaska, J. Every step of the way: Integrins in cancer progression and metastasis. Nat. Rev. Cancer 18(9), 533–548 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo, W. & Giancotti, F. G. Integrin signalling during tumour progression. Nat. Rev. Mol. Cell. Biol. 5(10), 816–826 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Loeser, H. et al. Integrin alpha V (ITGAV) expression in esophageal adenocarcinoma is associated with shortened overall-survival. Sci. Rep. 10(1), 18411 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fujita, S., Watanabe, M., Kubota, T., Teramoto, T. & Kitajima, M. Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer. Cancer Lett. 91(1), 145–149 (1995).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Trerotola, M. et al. Trop-2 promotes prostate cancer metastasis by modulating beta(1) integrin functions. Cancer Res. 73(10), 3155–3167 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schiffmann, L. M. et al. Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma. BMC Cancer 19(1), 531 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Plum, P. S. et al. HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma. BMC Cancer 19(1), 38 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schroder, W. et al. Ivor-Lewis esophagectomy with and without laparoscopic conditioning of the gastric conduit. World J. Surg. 34(4), 738–743 (2010).

    Article 
    PubMed 

    Google Scholar
     

  • Holscher, A. H., Schneider, P. M., Gutschow, C. & Schroder, W. Laparoscopic ischemic conditioning of the stomach for esophageal replacement. Ann. Surg. 245(2), 241–246 (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Messager, M. et al. Laparoscopic gastric mobilization reduces postoperative mortality after esophageal cancer surgery: A French nationwide study. Ann. Surg. 262(5), 817–822 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Mariette, C. et al. Hybrid minimally invasive esophagectomy for esophageal cancer. N. Engl. J. Med. 380(2), 152–162 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Simon, R., Mirlacher, M. & Sauter, G. Tissue microarrays. Methods Mol. Med. 114, 257–268 (2005).

    CAS 
    PubMed 

    Google Scholar
     

  • Essakly, A. et al. PIK3CA and KRAS amplification in esophageal adenocarcinoma and their impact on the inflammatory tumor microenvironment and prognosis. Transl. Oncol. 13(2), 157–164 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Schiffmann, L. M. et al. Dickkopf-2 (DKK2) as context dependent factor in patients with esophageal adenocarcinoma. Cancers (Basel) 12(2), 451 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schallenberg, S. et al. Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma. BMC Cancer 20(1), 12 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Loeser, H. et al. The expression of the immune checkpoint regulator VISTA correlates with improved overall survival in pT1/2 tumor stages in esophageal adenocarcinoma. Oncoimmunology 8(5), e1581546 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jahangiri, A., Aghi, M. K. & Carbonell, W. S. beta1 integrin: Critical path to antiangiogenic therapy resistance and beyond. Cancer Res. 74(1), 3–7 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Al-Jamal, R. & Harrison, D. J. Beta1 integrin in tissue remodelling and repair: From phenomena to concepts. Pharmacol. Ther. 120(2), 81–101 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kato, H. et al. The primacy of beta1 integrin activation in the metastatic cascade. PLoS ONE 7(10), e46576 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schober, M. & Fuchs, E. Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signaling. Proc. Natl. Acad. Sci. U. S. A. 108(26), 10544–10549 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527(7578), 329–335 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Trerotola, M. et al. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget 6(16), 14318–14328 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bardia, A. et al. Sacituzumab govitecan in metastatic triple-negative breast cancer. N. Engl. J. Med. 384(16), 1529–1541 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bardia, A. et al. Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: Final safety and efficacy results from the phase I/II IMMU-132-01 basket trial. Ann. Oncol. 32, 746–756. https://doi.org/10.1016/j.annonc.2021.03.005 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Nam, J. M., Chung, Y., Hsu, H. C. & Park, C. C. Beta1 integrin targeting to enhance radiation therapy. Int. J. Radiat. Biol. 85(11), 923–928 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie, Y.-H. et al. Role of integrin beta1 in the progression and chemoresistance of of esophageal squamous cell carcinoma. J. Cancer 13, 2074–2085. https://doi.org/10.7150/jca.68647 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Salem, M. E. et al. Comparative molecular analyses of esophageal squamous cell carcinoma, esophageal adenocarcinoma, and gastric adenocarcinoma. Oncologist 23, 1319–1327. https://doi.org/10.1634/theoncologist.2018-0143 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     



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