Spotlight on the November 29 Issue

Notable in Neurology This Week

This issue features an article that investigates racial disparities in stroke recurrence; another reports on the long-term clinical outcomes of rituximab treatment in patients with neuromyelitis optica spectrum disorder and MOG antibody disease. A featured Contemporary Issues in Practice, Education, & Research discusses best practices of handling sensitive information regarding preclinical Alzheimer disease in the electronic health record.

Research Articles

APOE Alleles With Tau and Aβ Pathology in Patients With Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex in the Kii Peninsula

Researchers analyzed APOE polymorphisms in 18 autopsy patients with amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) in the Kii peninsula of Japan and revealed the relationship between APOE polymorphisms and tau pathology. Their findings suggested that the APOE ε2 allele is associated with increased tau pathology in patients with Kii ALS/PDC.

Page 978

Air Pollution Associated With Incident Stroke, Poststroke Cardiovascular Events, and Death: A Trajectory Analysis of a Prospective Cohort

Air pollution is a risk factor of stroke. This study reported that air pollution was associated with dynamic transitions from healthy state to stroke, poststroke cardiovascular events, and death, with a stronger effect for transition from health to stroke. Efforts to reduce exposures may be most beneficial to primary stroke prevention.

Page 982

Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms

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This prospective, observational study followed children aged 2–24 months with new-onset infantile spasms treated with standard therapy. Treatment response occurred within 7 days for most patients with infantile spasms, suggesting that clinicians should reassess infantile spasms treatment at 1 week to determine whether additional treatment is necessary.

Page 984

Investigating Functional Network Abnormalities and Associations With Disability in Multiple Sclerosis

In this multicenter cross-sectional study, centrality analysis captured reconfiguration and topography changes of functional networks that were continuously occurring in multiple sclerosis. In this disease, centrality was reduced in sensorimotor and salience networks, and it increased in the default-mode network, with specific findings for phenotype and disability. Centrality may be a valuable marker for multiple sclerosis severity.

Page 986

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