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Can Norovirus Trigger Crohn’s? Phase III NASH Trial Flops; Social Isolation in IBD


Is norovirus infection triggering Crohn’s disease in people with certain genetic mutations? (NBC News)

The phase III REVERSE trial of obeticholic acid (Ocaliva) for compensated cirrhosis caused by non-alcoholic steatohepatitis (NASH) failed to meet its primary endpoint, Intercept Pharmaceuticals announced.

Real-world data from the SUCCESS consortium support the efficacy and safety of ustekinumab (Stelara) in Crohn’s disease, with the greatest benefit observed in the biologic-naive. (American Journal of Gastroenterology)

Severe and constant pain in patients with chronic pancreatitis are major drivers of poor health. (Clinical Gastroenterology and Hepatology)

Tumor necrosis factor (TNF) inhibitors showed benefit in preventing Crohn’s disease recurrence after bowel resection, even in those who previously failed on the biologics, according to French researchers. (Digestive and Liver Disease)

Patients with gastrointestinal conditions gave telehealth a thumbs up. (Gastroenterology)

Time to recommend more freshwater fish for fatty liver disease patients? (American Journal of Gastroenterology)

Women with polycystic ovarian syndrome had a nearly twofold higher risk of pancreatic cancer, even after adjusting for confounders, according to a research letter in JAMA Oncology.

You don’t say: in a randomized trial in Japan, prune juice was deemed safe and effective in relieving chronic constipation. (American Journal of Gastroenterology)

Socially isolated patients with inflammatory bowel disease (IBD), especially those with Crohn’s disease, were more likely to die early. (Therapeutic Advances in Gastroenterology)

Does warmer weather spur on more cases of appendicitis? (JAMA Network Open)

Risk for graft failure with livers positive for hepatitis C virus was no longer significantly increased during the era of direct-acting antivirals. (JAMA Surgery)

  • Zaina Hamza is a staff writer for MedPage Today, covering Gastroenterology and Infectious disease. She is based in Chicago.



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