Purpose of review:
Adult congenital heart disease (ACHD) patients have demonstrated improved survival, especially those with severely complex disease, mainly single-ventricle/Fontan physiology and those with a systemic right ventricle. We describe the heart failure phenotypes of complex CHD, reversible causes for heart failure, and considerations for advanced therapy.
While initially marketed for application to patients with acquired causes for heart failure, newer devices and technologies have started to be used in the ACHD population. After reversible causes for heart failure in CHD are addressed, it is reasonable to consider use of new device-based technologies and orthotopic heart transplant (OHT) for end-stage disease. New heart failure technology and organ transplant should carefully be considered and applied in complex ACHD, where there may be significant improvement in morbidity and mortality.
Adult congenital heart disease; Heart failure; Mechanical circulatory support; Orthotopic heart transplant.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Abstracts of Presentations at the Association of Clinical Scientists 143rd Meeting Louisville, KY May 11-14,2022.
Ann Clin Lab Sci. 2022 May;52(3):511-525.
Ann Clin Lab Sci. 2022.
Orthotopic heart transplantation in patients with univentricular physiology.
Curr Cardiol Rev. 2011 May;7(2):85-91. doi: 10.2174/157340311797484259.
Curr Cardiol Rev. 2011.
Free PMC article.
Outcomes following implantation of mechanical circulatory support in adults with congenital heart disease: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS).
J Heart Lung Transplant. 2018 Jan;37(1):89-99. doi: 10.1016/j.healun.2017.03.005. Epub 2017 Mar 7.
J Heart Lung Transplant. 2018.
Overview of adult congenital heart transplants.
Ann Cardiothorac Surg. 2018 Jan;7(1):143-151. doi: 10.21037/acs.2018.01.01.
Ann Cardiothorac Surg. 2018.
Free PMC article.
Ventricular assist device for end-stage adult congenital heart disease patients: Current status.
J Cardiol. 2022 Sep 21:S0914-5087(22)00230-1. doi: 10.1016/j.jjcc.2022.09.007. Online ahead of print.
J Cardiol. 2022.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Mano T. Trends in mortality of adult congenital heart disease patients in the last 4 decades. In: Viegas J, editor. Eur Heart J. 2016.