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Author Response: Prolonged Cardiac Monitoring and Stroke Recurrence: A Meta-analysis


We appreciate Dr. Meinel’s feedback on our study.1 The prevention of ischemic and hemorrhagic cerebrovascular events has been the desired objective (and component of the primary end point) in most large-scale antithrombotic trials. Although extracranial bleeding events are more common than intracranial hemorrhage events, neurologists should remember that the latter are associated with significantly higher morbidity and mortality. According to a large cohort study of adults with atrial fibrillation hospitalized for warfarin-associated intracranial or major extracranial hemorrhage, intracranial hemorrhages caused approximately 90% of the deaths and most disability among survivors.2



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