Spotlight on the August 30 Issue

Notable in Neurology This Week

This issue features an article that examines the association between sex, menopause, and white matter hyperintensities; another determines optimal surveillance strategies for unruptured intracranial aneurysm growth. A featured article examines the association of healthy lifestyles with risk of Alzheimer disease and related dementias in low-income Black and White Americans.


Quantitative Muscle Analysis in FSHD Using Whole-Body Fat-Referenced MRI: Composite Scores for Longitudinal and Cross-sectional Analysis

This prospective, observational, multicenter study in patients with facioscapulohumeral muscular dystrophy (FSHD) type 1 demonstrated that a quantitative whole-body musculoskeletal MRI (WB-MSK-MRI) protocol to evaluate muscles provides reliable measurements of muscle health, capturing disease heterogeneity and clinically meaningful composite assessments that correlate with disease severity and that may be responsive to clinical progression.

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Plasma-Soluble Dipeptidyl Peptidase-4 and Risk of Major Cardiovascular Events After Ischemic Stroke: Secondary Analysis of China Antihypertensive Trial in Acute Ischemic Stroke (CATIS)

This study examines the relationship between plasma-soluble dipeptidyl peptidase-4 (sDPP4) levels and clinical outcomes among patients with ischemic stroke. Higher plasma sDPP4 levels were associated with decreased risk of cardiovascular events, recurrent stroke, all-cause mortality, and poor functional outcomes, suggesting that plasma sDPP4 may be a potential prognostic marker for initial risk stratification.

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Determining the Minimal Important Change of Everyday Functioning in Dementia: Pursuing Clinical Meaningfulness

This study determined what constitutes a clinically meaningful change in everyday functioning and investigated how often meaningful change occurred within a year for persons living with dementia. Nearly half of unselected participants showed a meaningful decline in less than a year, and disease stage and medial temporal atrophy were predictors of functional decline greater than the minimal important change.

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