Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

. 2022 Aug 22;37(33):e254.

doi: 10.3346/jkms.2022.37.e254.


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Keon-Joo Lee et al.

J Korean Med Sci.



This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.


Event Outcome; Ischemic Attack, Transient; Minor Ischemic Stroke; Stroke Recurrence.

Conflict of interest statement

Authors Lesén E, Hedberg J, Tank A and Fita EG are employees of AstraZeneca. Independent of the submitted work, Bae HJ reports: grants from AstraZeneca Korea, Bayer, BMS Korea, Boehringer Ingelheim, Daichi Sankyo, Dong-A Pharmaceutical, Korean Drug Co. Ltd., Servier, Shin Poong Pharm. Co. Ltd and Yuhan Corporation; grants and personal fees from ESAI-Korea and Shire Korea Ltd; and personal fees from Amgen Asia Holding Limited, and Otsuka Korea outside the submitted work. The other authors report no conflicts.

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