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Timing stroke: A review on stroke pathophysiology and its influence over time on diffusion measures


  • The diversity and disparity of the glial scar.

    Nat. Neurosci. 2018; 21: 9-15https://doi.org/10.1038/s41593-017-0033-9

    • Albach F.N.
    • Brunecker P.
    • Usnich T.
    • Villringer K.
    • Ebinger M.
    • Fiebach J.B.
    • Nolte C.H.

    Complete early reversal of diffusion-weighted imaging hyperintensities after ischemic stroke is mainly limited to small embolic lesions.

    Stroke. 2013; 44: 1043-1048https://doi.org/10.1161/STROKEAHA.111.676346

    • Alegiani A.C.
    • MacLean S.
    • Braass H.
    • Gellißen S.
    • Cho T.H.
    • Derex L.
    • Thomalla G.

    Dynamics of water diffusion changes in different tissue compartments from acute to chronic stroke—a serial diffusion tensor imaging study.

    Front. Neurol. 2019; 10: 1-7https://doi.org/10.3389/fneur.2019.00158

    • Alexander A.L.
    • Lee J.E.
    • Lazar M.
    • Field A.S.

    Diffusion tensor imaging of the brain.

    Neurotherapeutics. 2007; 4: 316-329https://doi.org/10.1016/j.nurt.2007.05.011

    • Alia C.
    • Spalletti C.
    • Lai S.
    • Panarese A.
    • Lamola G.
    • Bertolucci F.
    • Caleo M.

    Neuroplastic changes following brain ischemia and their contribution to stroke recovery: novel approaches in neurorehabilitation.

    Front. Cell. Neurosci. 2017; 11: 1-22https://doi.org/10.3389/fncel.2017.00076

  • Inflammation and stroke: an overview.

    Neurotherapeutics. 2016; 13: 661-670https://doi.org/10.1007/s13311-016-0483-x

    • Axer H.
    • Gräßel D.
    • Brämer D.
    • Fitzek S.
    • Kaiser W.A.
    • Witte O.W.
    • Fitzek C.

    Time course of diffusion imaging in acute brainstem infarcts.

    J. Magn. Reson. Imaging. 2007; 26: 905-912https://doi.org/10.1002/jmri.21088

  • Antiedema therapy in ischemic stroke.

    Stroke. 2007; 38: 3084-3094https://doi.org/10.1161/STROKEAHA.107.490193

    • Baril A.A.
    • Gagnon K.
    • Descoteaux M.
    • Bedetti C.
    • Chami S.
    • Sanchez E.
    • Gosselin N.

    Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.

    Hum. Brain Mapp. 2020; 41: 2686-2701https://doi.org/10.1002/hbm.24971

    • Baron C.A.
    • Lla Kate M.
    • Gioia L.
    • Butcher K.
    • Emery D.
    • Budde M.
    • Beaulieu C.

    Reduction of diffusion-weighted imaging contrast of acute ischemic stroke at short diffusion times.

    Stroke. 2015; 46: 2136-2141https://doi.org/10.1161/STROKEAHA.115.008815

    • Battey T.W.K.
    • Karki M.
    • Singhal A.B.
    • Wu O.
    • Sadaghiani S.
    • Campbell B.C.V.
    • Kimberly W.T.

    Brain edema predicts outcome after nonlacunar ischemic stroke.

    Stroke. 2014; 45: 3643-3648https://doi.org/10.1161/STROKEAHA.114.006884

  • The biological basis of diffusion anisotropy.

    in: Diffusion MRI: From Quantitative Measurement to In vivo Neuroanatomy: Second Edition (Second Edi). 2013https://doi.org/10.1016/B978-0-12-396460-1.00008-1

    • Belov Kirdajova D.
    • Kriska J.
    • Tureckova J.
    • Anderova M.

    Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells.

    Front. Cell. Neurosci. 2020; 14: 1-27https://doi.org/10.3389/fncel.2020.00051

    • Bernhardt J.
    • Hayward K.S.
    • Kwakkel G.
    • Ward N.S.
    • Wolf S.L.
    • Borschmann K.
    • Cramer S.C.

    Agreed definitions and a shared vision for new standards in stroke recovery research: the stroke recovery and rehabilitation roundtable taskforce.

    Int. J. Stroke. 2017; 12: 444-450https://doi.org/10.1177/1747493017711816

    • Bhagat Y.A.
    • Hussain M.S.
    • Stobbe R.W.
    • Butcher K.S.
    • Emery D.J.
    • Shuaib A.
    • Beaulieu C.

    Elevations of diffusion anisotropy are associated with hyper-acute stroke: a serial imaging study.

    Magn. Reson. Imaging. 2008; 26: 683-693https://doi.org/10.1016/j.mri.2008.01.015

    • Boukadi M.
    • Marcotte K.
    • Bedetti C.
    • Houde J.-C.
    • Desautels A.
    • Deslauriers-Gauthier S.
    • Brambati S.M.

    Test-retest reliability of diffusion measures extracted along white matter language fiber bundles using HARDI-based tractography.

    Front. Neurosci. 2019; 12: 1055https://doi.org/10.3389/fnins.2018.01055

    • Broocks G.
    • Faizy T.D.
    • Flottmann F.
    • Schön G.
    • Langner S.
    • Fiehler J.
    • Gellissen S.

    Subacute infarct volume with edema correction in computed tomography is equivalent to final infarct volume after ischemic stroke: improving the comparability of infarct imaging endpoints in clinical trials.

    Investig. Radiol. 2018; 53: 472-476https://doi.org/10.1097/RLI.0000000000000475

    • Budde M.D.
    • Janes L.
    • Gold E.
    • Turtzo L.C.
    • Frank J.A.

    The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections.

    Brain. 2011; 134: 2248-2260https://doi.org/10.1093/brain/awr161

  • Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.

    Curr. Opin. Investig. Drugs. 2009; 10: 644-654

    • Carmichael S.T.
    • Kathirvelu B.
    • Schweppe C.A.
    • Nie E.H.

    Molecular, cellular and functional events in axonal sprouting after stroke.

    Exp. Neurol. 2017; 287: 384-394https://doi.org/10.1016/j.expneurol.2016.02.007.Molecular

    • Cho A.H.
    • Sohn S. Il
    • Han M.K.
    • Lee D.H.
    • Kim J.S.
    • Choi C.G.
    • Kang D.W.

    Safety and efficacy of MRI-based thrombolysis in unclear-onset stroke: a preliminary report.

    Cerebrovasc. Dis. 2008; 25: 572-579https://doi.org/10.1159/000132204

  • A macroscopic view of microstructure: using diffusion-weighted images to infer damage, repair, and plasticity of white matter.

    Neuroscience. 2014; 276: 14-28https://doi.org/10.1016/j.neuroscience.2013.09.004

    • Curran K.M.
    • Emsell L.
    • Leemans A.

    Quantitative DTI measures.

    in: Diffusion Tensor Imaging: A Practical Handbook. 2016: 65-87https://doi.org/10.1007/978-1-4939-3118-7

    • De Figuereido E.H.M.S.G.
    • Borgonovi A.F.N.G.
    • Doring T.M.

    Basic concepts of MR imaging, diffusion mr imaging, and diffusion tensor imaging.

    Magnet. Reson. Imag. Clin. NA. 2011; 19: 1-22https://doi.org/10.1016/j.mric.2010.10.005

    • Dumont M.
    • Roy M.
    • Jodoin P.M.
    • Morency F.C.
    • Houde J.C.
    • Xie Z.
    • Descoteaux M.

    Free water in white matter differentiates MCI and AD from control subjects.

    Front. Aging Neurosci. 2019; 11: 1-9https://doi.org/10.3389/fnagi.2019.00270

    • Dziewulska D.
    • Mossakowski M.

    Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke.

    Clin. Neuropathol. 2003; 22: 35-40

    • Farquharson S.
    • Tournier J.-D.

    High angular resolution diffusion imaging.

    in: Diffusion Tensor Imaging: A Practical Handbook. 2016: 383-406https://doi.org/10.1007/978-1-4939-3118-7

    • Fragata I.
    • Alves M.
    • Papoila A.L.
    • Ferreira P.
    • Nunes A.P.
    • Moreira N.C.
    • Canhão P.

    Prediction of clinical outcome in subacute subarachnoid hemorrhage using diffusion tensor imaging.

    J. Neurosurg. 2019; 130: 550-558https://doi.org/10.3171/2017.10.JNS171793.550

    • Froeling M.
    • Pullens P.
    • Leemans A.

    DTI analysis methods: region of interest analysis.

    in: Diffusion Tensor Imaging: A Practical Handbook. 2016: 175-182https://doi.org/10.1007/978-1-4939-3118-7

    • Fu Y.
    • Liu Q.
    • Anrather J.
    • Shi F.

    Immune interventions in stroke.

    Nat. Rev. Neurol. 2015; 11: 524-535https://doi.org/10.1038/nrneurol.2015.144.Immune

    • Harris A.D.
    • Pereira R.S.
    • Mitchell J.R.
    • Hill M.D.
    • Sevick R.J.
    • Frayne R.

    A comparison of images generated from diffusion-weighted and diffusion-tensor imaging data in hyper-acute stroke.

    J. Magn. Reson. Imaging. 2004; 20: 193-200https://doi.org/10.1002/jmri.20116

    • Ho M.L.
    • Rojas R.
    • Eisenberg R.L.

    Cerebral edema.

    Am. J. Roentgenol. 2012; 199https://doi.org/10.2214/AJR.11.8081

    • Ivanova M.V.
    • Yu D.
    • Dragoy O.V.
    • Shklovsky V.M.
    • Dronkers N.F.

    Diffusion-tensor imaging of major white matter tracts and their role in language processing in aphasia.

    Cortex. 2016; 85: 165-181https://doi.org/10.1016/j.cortex.2016.04.019

    • Jayaraj R.L.
    • Azimullah S.
    • Beiram R.
    • Jalal F.Y.
    • Rosenberg G.A.

    Neuroinflammation: friend and foe for ischemic stroke.

    J. Neuroinflammation. 2019; 16: 1-24https://doi.org/10.1186/s12974-019-1516-2

    • Johnson C.O.
    • Nguyen M.
    • Roth G.A.
    • Nichols E.
    • Alam T.
    • Abate D.
    • Murray C.J.L.

    Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the global burden of disease study 2016.

    Lancet Neurol. 2019; 18: 439-458https://doi.org/10.1016/S1474-4422(19)30034-1

    • Jones D.K.
    • Knösche T.R.
    • Turner R.

    White matter integrity, fiber count, and other fallacies: the do’s and don’ts of diffusion MRI.

    NeuroImage. 2012; https://doi.org/10.1016/j.neuroimage.2012.06.081

    • Kidwell C.S.
    • Saver J.L.
    • Mattiello J.
    • Starkman S.
    • Vinuela F.
    • Duckwiler G.
    • Alger J.R.

    Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging.

    Ann. Neurol. 2000; 47: 462-469https://doi.org/10.1002/1531-8249(200004)47:4<462::aid-ana9>3.3.co;2-p

    • Kimura-Ohba S.
    • Yang Y.
    • Thompson J.
    • Kimura T.
    • Salayandia V.M.
    • Cosse M.
    • Rosenberg G.A.

    Transient increase of fractional anisotropy in reversible vasogenic edema.

    J. Cereb. Blood Flow Metab. 2016; 36: 1731-1743https://doi.org/10.1177/0271678X16630556

    • Kliper E.
    • Bashat D. Ben
    • Bornstein N.M.
    • Shenhar-Tsarfaty S.
    • Hallevi H.
    • Auriel E.
    • Assayag E. Ben

    Cognitive decline after stroke: relation to inflammatory biomarkers and hippocampal volume.

    Stroke. 2013; 44: 1433-1435https://doi.org/10.1161/STROKEAHA.111.000536

  • Apparent diffusion coefficient and beyond: what diffusion mr imaging can tell us about tissue structure.

    Radiology. 2013; 268: 318-322https://doi.org/10.1148/radiol.13130420

    • Leinonen V.
    • Vanninen R.
    • Rauramaa T.

    Raised intracranial pressure and brain edema.

    in: Handbook of Clinical Neurology. 1st ed. Vol. 145. 2018https://doi.org/10.1016/B978-0-12-802395-2.00004-3

  • Remyelination is critical for white matter stroke recovery.

    Europ. J. BioMed. Res. 2015; 1: 18-22https://doi.org/10.18088/ejbmr.1.4.2015.pp18-22

  • Imaging of ischemic stroke.

    CONTINUUM Lifelong Learn. Neurol. 2016; 22: 1399-1423https://doi.org/10.1212/CON.0000000000000376

    • Liu Y.
    • D’Arceuil H.E.
    • Westmoreland S.
    • He J.
    • Duggan M.
    • Gonzalez R.G.
    • De Crespigny A.J.

    Serial diffusion tensor MRI after transient and permanent cerebral ischemia in nonhuman primates.

    Stroke. 2007; 38: 138-145https://doi.org/10.1161/01.STR.0000252127.07428.9c

  • Pathogenesis of brain edema and investigation into anti-edema drugs.

    Int. J. Mol. Sci. 2015; 16: 9949-9975https://doi.org/10.3390/ijms16059949

    • Montal V.
    • Vilaplana E.
    • Alcolea D.
    • Pegueroles J.
    • Pasternak O.
    • Gonz S.
    • Mart P.

    Cortical microstructural changes along the Alzheimer’s disease continuum.

    Alzheimers Dement. 2017; 14: 340-351https://doi.org/10.1016/j.jalz.2017.09.013

    • Moulton E.
    • Magno S.
    • Valabregue R.
    • Amor-sahli M.
    • Pires C.
    • Lehéricy S.
    • Rosso C.

    Acute diffusivity biomarkers for prediction of motor and language outcome in mild-to-severe stroke patients.

    Stroke. 2019; 50: 1-7https://doi.org/10.1161/STROKEAHA.119.024946

    • Nael K.
    • Trouard T.P.
    • Lafleur S.R.
    • Krupinski E.A.
    • Salamon N.
    • Kidwell C.S.

    White matter ischemic changes in hyperacute ischemic stroke: voxel-based analysis using diffusion tensor imaging and MR perfusion.

    Stroke. 2015; 46: 413-418https://doi.org/10.1161/STROKEAHA.114.007000

    • Nagaraja N.
    • Forder J.R.
    • Warach S.
    • Merino J.G.

    Reversible diffusion-weighted imaging lesions in acute ischemic stroke: a systematic review.

    Neurology. 2020; 94: 571-587https://doi.org/10.1212/WNL.0000000000009173

    • Narasimhalu K.
    • Lee J.
    • Leong Y.L.
    • Ma L.
    • De Silva D.A.
    • Wong M.C.
    • Chen C.

    Inflammatory markers and their association with post stroke cognitive decline.

    Int. J. Stroke. 2015; 10: 513-518https://doi.org/10.1111/ijs.12001

    • Pinter D.
    • Gattringer T.
    • Fandler-Höfler S.
    • Kneihsl M.
    • Eppinger S.
    • Deutschmann H.
    • Enzinger C.

    Early progressive changes in white matter integrity are associated with stroke recovery.

    Transl. Stroke Res. 2020; https://doi.org/10.1007/s12975-020-00797-x

    • Pitkonen M.
    • Abo-Ramadan U.
    • Marinkovic I.
    • Pedrono E.
    • Hasan K.M.
    • Strbian D.
    • Tatlisumak T.

    Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats.

    Brain Res. 2012; 1445: 103-110https://doi.org/10.1016/j.brainres.2012.01.043

    • Ringer T.M.
    • Neumann-Haefelin T.
    • Sobel R.A.
    • Moseley M.E.
    • Yenari M.A.

    Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia.

    Stroke. 2001; 32: 2362-2369https://doi.org/10.1161/hs1001.096058

    • Rivers C.S.
    • Wardlaw J.M.
    • Armitage P.A.
    • Bastin M.E.
    • Carpenter T.K.
    • Cvoro V.
    • Dennis M.S.

    Persistent infarct hyperintensity on diffusion-weighted imaging late after stroke indicates heterogeneous, delayed, infarct evolution.

    Stroke. 2006; 37: 1418-1423https://doi.org/10.1161/01.STR.0000221294.90068.c4

    • Rowe M.
    • Siow B.
    • Alexander D.C.
    • Ferizi U.
    • Richardson S.

    Concepts of diffusion in MRI.

    in: Diffusion Tensor Imaging: A Practical Handbook. 2016: 23-35https://doi.org/10.1007/978-1-4939-3118-7

  • Resolution of inflammation during multiple sclerosis.

    Semin. Immunopathol. 2019; 41: 711-726https://doi.org/10.1007/s00281-019-00765-0

    • Schellinger P.D.
    • Bryan R.N.
    • Caplan L.R.
    • Detre J.A.
    • Edelman R.R.
    • Jaigobin C.
    • Warach S.

    Evidence-based guideline: the role of diffusion and perfusion mri for the diagnosis of acute ischemic stroke: report of the therapeutics and technology subcommittee of the American Academy of Neurology.

    Neurology. 2010; 75: 175-185https://doi.org/10.1212/WNL.0b013e318219a0b4

    • Schirmer M.D.
    • Giese A.-K.
    • Fotiadis P.
    • Etherton M.R.
    • Cloonan L.
    • Viswanathan A.
    • Rost N.S.

    Spatial signature of white matter Hyperintensities in stroke patients.

    Front. Neurol. 2019; 10: 1-10https://doi.org/10.3389/fneur.2019.00208

    • Shereen A.
    • Nemkul N.
    • Yang D.
    • Adhami F.
    • Dunn R.S.
    • Hazen M.L.
    • Kuan C.Y.

    Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke.

    J. Cereb. Blood Flow Metab. 2011; 31: 1155-1169https://doi.org/10.1038/jcbfm.2010.212

    • Shi K.
    • Tian D.C.
    • Li Z.G.
    • Ducruet A.F.
    • Lawton M.T.
    • Shi F.D.

    Global brain inflammation in stroke.

    Lancet Neurol. 2019; 18: 1058-1066https://doi.org/10.1016/S1474-4422(19)30078-X

    • Simard J.
    • Kent T.
    • Chen M.
    • Tarasov K.
    • Gerzanich V.

    Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications.

    Lancet Neurol. 2007; 6: 258-268https://doi.org/10.1016/S1474-4422(07)70055-8. Brain

    • Soares J.M.
    • Marques P.
    • Alves V.
    • Sousa N.

    A hitchhiker’s guide to diffusion tensor imaging.

    Front. Neurosci. 2013; https://doi.org/10.3389/fnins.2013.00031

    • Song S.K.
    • Sun S.W.
    • Ju W.K.
    • Lin S.J.
    • Cross A.H.
    • Neufeld A.H.

    Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia.

    NeuroImage. 2003; 20: 1714-1722https://doi.org/10.1016/j.neuroimage.2003.07.005

    • Song S.K.
    • Sun S.W.
    • Ramsbottom M.J.
    • Chang C.
    • Russell J.
    • Cross A.H.

    Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water.

    NeuroImage. 2002; https://doi.org/10.1006/nimg.2002.1267

  • The role of diffusion tensor imaging in the evaluation of ischemic brain injury – a review.

    NMR Biomed. 2002; 15: 561-569https://doi.org/10.1002/nbm.786

    • Srivastava A.K.
    • Mehrotra G.
    • Bhargava S.K.
    • Agarwal S.
    • Tripathi R.P.

    Studies on the time course of apparent diffusion coefficient and signal intensities on T2- and diffusion-weighted MR imaging in acute cerebral ischemic stroke.

    J. Med. Phys. 2008; 33: 162-170https://doi.org/10.4103/0971-6203.44479

    • Strbian D.
    • Meretoja A.
    • Putaala J.
    • Kaste M.
    • Tatlisumak T.
    • Ville A.
    • Marjaana T.

    Cerebral edema in acute ischemic stroke patients treated with intravenous thrombolysis.

    Int. J. Stroke. 2013; 8: 529-534https://doi.org/10.1111/j.1747-4949.2012.00781.x

    • Sun S.W.
    • Liang H.F.
    • Trinkaus K.
    • Cross A.H.
    • Armstrong R.C.
    • Song S.K.

    Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum.

    Magn. Reson. Med. 2006; 55: 302-308https://doi.org/10.1002/mrm.20774

    • Szczepankiewicz F.
    • Lätt J.
    • Wirestam R.
    • Leemans A.
    • Sundgren P.
    • Van Westen D.
    • Nilsson M.

    NeuroImage variability in diffusion kurtosis imaging : impact on study design, statistical power and interpretation.

    NeuroImage. 2013; 76: 145-154https://doi.org/10.1016/j.neuroimage.2013.02.078

    • Tae W.
    • Ham B.-J.
    • Pyun S.-B.
    • Kang S.-H.
    • Kim B.-J.

    Current clinical applications of diffusion-tensor imaging in neurological disorders.

    J. Clin. Neurol. 2018; 14: 129-140https://doi.org/10.3988/jcn.2018.14.2.129

    • Theaud G.
    • Houde J.C.
    • Boré A.
    • Rheault F.
    • Morency F.
    • Descoteaux M.

    TractoFlow: a robust, efficient and reproducible diffusion MRI pipeline leveraging Nextflow & Singularity.

    NeuroImage. 2020; 218https://doi.org/10.1016/j.neuroimage.2020.116889

    • Tipirneni-Sajja A.
    • Christensen S.
    • Straka M.
    • Inoue M.
    • Lansberg M.G.
    • Mlynash M.
    • Albers G.W.

    Prediction of final infarct volume on subacute MRI by quantifying cerebral edema in ischemic stroke.

    J. Cereb. Blood Flow Metab. 2017; 37: 3077-3084https://doi.org/10.1177/0271678X16683960

    • Tsai Y.H.
    • Hsu L.M.
    • Weng H.H.
    • Lee M.H.
    • Yang J.T.
    • Lin C.P.

    Functional diffusion map as an imaging predictor of functional outcome in patients with primary intracerebral haemorrhage.

    Br. J. Radiol. 2013; 86: 1-8https://doi.org/10.1259/bjr.20110644

    • van Gelderen P.
    • de Vleeschouwer M.H.M.
    • DesPres D.
    • Pekar J.
    • van Zijl P.C.M.
    • Moonen C.T.W.

    Water diffusion and acute stroke.

    Magn. Reson. Med. 1994; 31: 154-163https://doi.org/10.1002/mrm.1910310209

  • Why is Wallerian degeneration in the CNS so slow?.

    Annu. Rev. Neurosci. 2007; 30: 153-179https://doi.org/10.1146/annurev.neuro.30.051606.094354

    • Visser M.M.
    • Yassi N.
    • Campbell B.C.V.
    • Desmond P.M.
    • Davis S.M.
    • Spratt N.
    • Bivard A.

    White matter degeneration after ischemic stroke: a longitudinal diffusion tensor imaging study.

    J. Neuroimaging. 2019; 29: 111-118https://doi.org/10.1111/jon.12556

    • Wanner I.B.
    • Anderson M.A.
    • Song B.
    • Levine J.
    • Fernandez A.
    • Gray-Thompson Z.
    • Sofroniew M.V.

    Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.

    J. Neurosci. 2013; 33: 12870-12886https://doi.org/10.1523/JNEUROSCI.2121-13.2013

    • Wardlaw J.M.
    • Chappell F.M.
    • Valdés Hernández M.D.C.
    • Makin S.D.J.
    • Staals J.
    • Shuler K.
    • Dennis M.S.

    White matter hyperintensity reduction and outcomes after minor stroke.

    Neurology. 2017; 89: 1003-1010https://doi.org/10.1212/WNL.0000000000004328

    • Winklewski P.J.
    • Sabisz A.
    • Naumczyk P.
    • Jodzio K.
    • Szurowska E.
    • Szarmach A.

    Understanding the physiopathology behind axial and radial diffusivity changes-what do we know?.

    Front. Neurol. 2018; 9https://doi.org/10.3389/fneur.2018.00092

    • Xie M.
    • Tobin J.E.
    • Budde M.D.
    • Chen C.
    • Trinkaus K.
    • Cross A.H.
    • Armstrong R.C.

    Rostro-caudal analysis of Corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features.

    J. Neuropathol. Exp. Neurol. 2011; 69: 704-716https://doi.org/10.1097/NEN.0b013e3181e3de90.Rostro-Caudal

    • Xing C.
    • Arai K.
    • Lo E.H.
    • Hommel M.

    Pathophysiologic cascades in ischemic stroke.

    Int. J. Stroke. 2012; 7: 378-385https://doi.org/10.1111/j.1747-4949.2012.00839.x

    • Zhang X.
    • Yan Y.
    • Tong F.
    • Li C.-X.
    • Jones B.
    • Wang S.
    • Howell L.

    Progressive assessment of ischemic injury to white matter using diffusion tensor imaging: a preliminary study of a macaque model of stroke.

    Open Neuroimag. J. 2018; 12: 30-41https://doi.org/10.2174/1874440001812010030



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